Reactome | LIG3 [nucleoplasm]

LIG3 [nucleoplasm]

Stable Identifier

R-HSA-53789

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA ligase III , Polydeoxyribonucleotide synthase (ATP)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49916 LIG3

Gene Names

LIG3

Chain

transit peptide:1-42, chain:43-1009

Reference Genes

BioGPS Gene:3980 LIG3

COSMIC (genes):LIG3 LIG3

CTD Gene:3980 LIG3

dbSNP Gene:3980 LIG3

ENSEMBL:ENSG00000005156 LIG3

HGNC:6600 LIG3

KEGG:hsa:3980 LIG3

Monarch:3980 LIG3

NCBI Gene:3980 LIG3

OMIM:600940 LIG3

UCSC:P49916 LIG3

Reference Transcript

Participates

as a component of

LIG3:XRCC1 [nucleoplasm] (Homo sapiens)

Inferred To

LIG3 [nucleoplasm] (Bos taurus)

LIG3 [nucleoplasm] (Canis familiaris)

LIG3 [nucleoplasm] (Gallus gallus)

LIG3 [nucleoplasm] (Sus scrofa)

DNAlig3 [nucleoplasm] (Drosophila melanogaster)

Lig3 [nucleoplasm] (Mus musculus)

Lig3 [nucleoplasm] (Rattus norvegicus)

lig3 [nucleoplasm] (Danio rerio)

lig3 [nucleoplasm] (Dictyostelium discoideum)

lig3 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002302.2, XP_016880113.1, NP_039269.2, XP_054172030.1

ENSEMBL

ENSP00000367787, ENST00000262327, ENST00000378526, ENSG00000005156, ENSP00000262327

OpenTargets

ENSG00000005156

GeneCards

LIG3

HPA

ENSG00000005156-LIG3

PRO

P49916

Pharos - Targets

P49916

GlyGen

P49916

HMDB Protein

HMDBP00607

PDB

1IN1, 1IMO, 1UW0, 3QVG, 3L2P, 6WH1, 3PC8, 3PC7

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.669	4
UniProt:P06746 POLB	2	POLB [nucleoplasm] (R-HSA-53845) PolyUb-POLB [nucleoplasm] (R-HSA-6783152)	0.643	4
UniProt:Q9NTX7 RNF146	1	RNF146 [cytosol] (R-HSA-3640827)	0.643	4
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.527	2
UniProt:P16104 H2AX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	3
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	3