Reactome | Ub-RibC-AXIN is degraded by the proteasome

Ub-RibC-AXIN is degraded by the proteasome

Stable Identifier

R-HSA-3640874

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ub-RibC-AXIN is degraded by the proteasome

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In the presence of the proteasome inhibitor MG132, polyubiquitinated forms of AXIN accumulate (Huang et al, 2009; Zhang et al, 2011; Callow et al, 2011). This effect is abrogated by co-treatment of cells with both MG132 and inhibitors of tankyrase activity, suggesting that both PARSylation and ubiquitination are required for AXIN degradation (Huang et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
21478859	RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling Mickanin, C, Zhang, Y, Shi, X, Charlat, O, Feng, Y, Cong, F, Schirle, M, Michaud, GA, Hild, M, Porter, JA, Bauer, A, Huang, SM, Myer, VE, Finan, PM, Liu, S	Nat. Cell Biol.	2011
19759537	Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling Mickanin, C, Zhang, Y, Fawell, S, Mishina, YM, Fazal, A, Myer, V, Wiellette, E, Michaud, GA, Wiessner, S, Hild, M, Bauer, A, Porter, JA, Rau, C, Huang, SM, Lengauer, C, Finan, PM, Ghidelli, S, Serluca, F, Shao, W, Bouwmeester, T, Shi, X, Stegmeier, F, Shultz, M, Charlat, O, Kirschner, MW, Cong, F, Schirle, M, Schlegl, J, Curtis, D, Wilson, CJ, Tallarico, JA, Cheng, H, Cheung, A, Liu, S, Lu, C, Tomlinson, R	Nature	2009
21799911	Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling Kirkpatrick, DS, Bheddah, S, Lau, T, Callow, MG, Lee, J, Davis, D, Sandoval, WN, Polakis, P, Tran, H, Lill, JR, Hongo, JA, Costa, M, Liu, PS, Tao, J, Phu, L	PLoS ONE	2011