Ub-RibC-AXIN is degraded by the proteasome

Stable Identifier
Reaction [omitted]
Homo sapiens
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In the presence of the proteasome inhibitor MG132, polyubiquitinated forms of AXIN accumulate (Huang et al, 2009; Zhang et al, 2011; Callow et al, 2011). This effect is abrogated by co-treatment of cells with both MG132 and inhibitors of tankyrase activity, suggesting that both PARSylation and ubiquitination are required for AXIN degradation (Huang et al, 2009).

Literature References
PubMed ID Title Journal Year
21478859 RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

Mickanin, C, Zhang, Y, Shi, X, Charlat, O, Feng, Y, Cong, F, Schirle, M, Michaud, GA, Hild, M, Porter, JA, Bauer, A, Huang, SM, Myer, VE, Finan, PM, Liu, S

Nat. Cell Biol. 2011
19759537 Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Mickanin, C, Zhang, Y, Fawell, S, Mishina, YM, Fazal, A, Myer, V, Wiellette, E, Michaud, GA, Wiessner, S, Hild, M, Bauer, A, Porter, JA, Rau, C, Huang, SM, Lengauer, C, Finan, PM, Ghidelli, S, Serluca, F, Shao, W, Bouwmeester, T, Shi, X, Stegmeier, F, Shultz, M, Charlat, O, Kirschner, MW, Cong, F, Schirle, M, Schlegl, J, Curtis, D, Wilson, CJ, Tallarico, JA, Cheng, H, Cheung, A, Liu, S, Lu, C, Tomlinson, R

Nature 2009
21799911 Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling

Kirkpatrick, DS, Bheddah, S, Lau, T, Callow, MG, Lee, J, Davis, D, Sandoval, WN, Polakis, P, Tran, H, Lill, JR, Hongo, JA, Costa, M, Liu, PS, Tao, J, Phu, L

PLoS ONE 2011
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
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