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CRADD [cytosol]
Stable Identifier
R-HSA-5657970
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RAIDD, Death domain-containing protein CRADD, Caspase and RIP adapter with death domain
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
PIDD1 associates with CRADD (Homo sapiens)
CRADD [cytosol] (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
CRADD [cytosol] (Homo sapiens)
The PIDDosome activates CASP2 (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
CRADD [cytosol] (Homo sapiens)
PIDDosome:CASP2(2-452) [cytosol] (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
CRADD [cytosol] (Homo sapiens)
The PIDDosome binds CASP2 (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
CRADD [cytosol] (Homo sapiens)
PIDDosome:CASP2(2-452) [cytosol] (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
CRADD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78560 CRADD
Gene Names
CRADD, RAIDD
Chain
chain:1-199
Reference Genes
BioGPS Gene:8738 CRADD
COSMIC (genes):CRADD CRADD
CTD Gene:8738 CRADD
dbSNP Gene:8738 CRADD
ENSEMBL:ENSG00000169372 CRADD
HGNC:2340 CRADD
KEGG:hsa:8738 CRADD
Monarch:8738 CRADD
NCBI Gene:8738 CRADD
OMIM:603454 CRADD
UCSC:P78560 CRADD
Reference Transcript
RefSeq:NM_001320099.1 CRADD
RefSeq:NM_003805.4 CRADD
RefSeq:NM_001320101.1 CRADD
RefSeq:XM_017020144.1 CRADD
RefSeq:NM_001320100.1 CRADD
Other Identifiers
11739913_a_at
11744421_a_at
11744422_s_at
11761849_s_at
1211_s_at
16755167
209833_PM_at
209833_at
3426306
3426307
3426308
3426309
3426310
3426312
3426334
3426336
3426337
3426349
3426363
3426364
3426365
3426374
3426379
3426380
3426381
3426383
3426384
3426415
3426416
7957560
822_s_at
8738
A_14_P133254
A_32_P29806
GE79088
GO:0002020
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0006915
GO:0006974
GO:0006977
GO:0007165
GO:0008625
GO:0012501
GO:0030674
GO:0042981
GO:0043065
GO:0043226
GO:0060090
GO:0070513
GO:0071260
GO:0097190
GO:1905369
GO:2001235
HMNXSV003045061
HMNXSV003045748
ILMN_1690282
PH_hs_0009369
TC12000728.hg
U79115_s_at
U84388_at
g1785556_3p_at
p3814
Participates
as an input of
PIDD1 associates with CRADD (Homo sapiens)
as a component of
PIDDosome [cytosol] (Homo sapiens)
Inferred To
Dronc [cytosol]
(Drosophila melanogaster)
Cradd [cytosol]
(Mus musculus)
Cradd [cytosol]
(Rattus norvegicus)
CRADD [cytosol]
(Bos taurus)
CRADD [cytosol]
(Canis familiaris)
Cross References
ENSEMBL
ENSP00000439068
,
ENSP00000327647
,
ENSG00000169372
,
ENST00000542893
,
ENSP00000448425
,
ENST00000551065
,
ENST00000332896
OpenTargets
ENSG00000169372
GeneCards
CRADD
HPA
ENSG00000169372-CRADD
PRO
P78560
Pharos - Targets
P78560
Orphanet
CRADD
PDB
2O71
,
3CRD
,
2OF5
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42575 CASP2
3
CASP2(2-452) [cytosol]
(R-HSA-622412)
CASP2(348-452) [cytosol]
(R-HSA-2976745)
CASP2(170-325) [cytosol]
(R-HSA-2976746)
0.973
32
UniProt:Q9HB75 PIDD1
3
p-T788-PIDD1 [cytosol]
(R-HSA-6800271)
p-T788-PIDD1 [nucleoplasm]
(R-HSA-6800485)
PIDD1 [nucleoplasm]
(R-HSA-6800483)
0.803
7
UniProt:Q8NEU8 DP13B
0.666
4
UniProt:Q7L273 KCTD9
0.556
3
UniProt:P35609 ACTN2
3
ACTN2 [cytosol]
(R-HSA-390562)
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [extracellular region]
(R-HSA-349725)
0.556
3
UniProt:P14079 TAX
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:Q8N3I7 BBS5
1
BBS5 [cytosol]
(R-HSA-5617633)
0.556
3
UniProt:Q9Y5W5 WIF1
1
WIF1 [extracellular region]
(R-HSA-3769320)
0.488
2
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