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p-T788-PIDD1 [cytosol]
Stable Identifier
R-HSA-6800271
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
PIDD1 associates with CRADD (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
p-T788-PIDD1 [cytosol] (Homo sapiens)
p-T788-PIDD1 [cytosol] (Homo sapiens)
PIDD1 translocates to the cytosol (Homo sapiens)
p-T788-PIDD1 [cytosol] (Homo sapiens)
The PIDDosome activates CASP2 (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
p-T788-PIDD1 [cytosol] (Homo sapiens)
PIDDosome:CASP2(2-452) [cytosol] (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
p-T788-PIDD1 [cytosol] (Homo sapiens)
The PIDDosome binds CASP2 (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
p-T788-PIDD1 [cytosol] (Homo sapiens)
PIDDosome:CASP2(2-452) [cytosol] (Homo sapiens)
PIDDosome [cytosol] (Homo sapiens)
p-T788-PIDD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HB75 PIDD1
Gene Names
PIDD1, LRDD, PIDD
Chain
initiator methionine:, chain:2-910, chain:2-445, chain:446-910, chain:589-910
Reference Genes
BioGPS Gene:55367 PIDD1
COSMIC (genes):PIDD1 PIDD1
CTD Gene:55367 PIDD1
dbSNP Gene:55367 PIDD1
ENSEMBL:ENSG00000177595 PIDD1
ENSEMBL_homo_sapiens_GENE:ENSG00000177595.19 PIDD1
HGNC:16491 PIDD1
KEGG Gene (Homo sapiens):55367 PIDD1
Monarch:55367 PIDD1
NCBI Gene:55367 PIDD1
OMIM:605247 PIDD1
UCSC:Q9HB75 PIDD1
Reference Transcript
RefSeq:NM_145886.3 PIDD1
RefSeq:XM_011520211.2 PIDD1
RefSeq:NM_145887.3 PIDD1
RefSeq:XM_017017993.1 PIDD1
RefSeq:XM_011520210.2 PIDD1
Other Identifiers
11724124_a_at
16734119
219019_PM_at
219019_at
221640_PM_s_at
221640_s_at
3358426
3358427
3358428
3358429
3358431
3358433
3358434
3358435
3358436
3358437
3358439
3358441
3358443
3358444
3358446
3358447
3358448
3358449
3358450
3358452
3358453
3358454
3358456
3358457
3358458
3358462
55367
57583_at
7945550
A_32_P117145
A_33_P3309319
GE62139
GO:0000278
GO:0003824
GO:0004175
GO:0005123
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005794
GO:0005829
GO:0006351
GO:0006355
GO:0006915
GO:0006919
GO:0006974
GO:0006977
GO:0007165
GO:0008625
GO:0012501
GO:0016540
GO:0016787
GO:0023052
GO:0043065
GO:0043066
GO:0043122
GO:0043226
GO:0051092
GO:0051604
GO:0097190
GO:0097191
GO:0140096
GO:1905369
HMNXSV003011559
ILMN_2400352
ILMN_2406552
PH_hs_0020829
TC11001248.hg
g10130018_3p_a_at
g8923912_3p_x_at
Participates
as a component of
PIDDosome [cytosol] (Homo sapiens)
as an input of
PIDD1 associates with CRADD (Homo sapiens)
as an output of
PIDD1 translocates to the cytosol (Homo sapiens)
Other forms of this molecule
p-T788-PIDD1 [nucleoplasm]
PIDD1 [nucleoplasm]
Inferred To
phospho-Phlpp [cytosol]
(Drosophila melanogaster)
phospho-PIDD1 [cytosol]
(Bos taurus)
phospho-PIDD1 [cytosol]
(Canis familiaris)
phospho-PIDD1 [cytosol]
(Sus scrofa)
phospho-Pidd1 [cytosol]
(Mus musculus)
phospho-Pidd1 [cytosol]
(Rattus norvegicus)
phospho-Dmel\CG10307 [cytosol]
(Drosophila melanogaster)
Homologues of p-T788-PIDD1 [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-threonine at 788
Coordinate
788
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_665893.2
,
XP_011518512.1
,
XP_016873482.1
,
NP_665894.2
,
XP_011518513.1
OpenTargets
ENSG00000177595
GeneCards
Q9HB75
HPA
ENSG00000177595-PIDD1
Ensembl
ENSP00000337797
,
ENST00000347755
,
ENST00000411829
,
ENSP00000416801
,
ENSG00000177595
PRO
Q9HB75
Pharos - Targets
Q9HB75
PDB
2OF5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78560 CRADD
1
CRADD [cytosol]
(R-HSA-5657970)
0.803
7
UniProt:P42575 CASP2
3
CASP2(170-325) [cytosol]
(R-HSA-2976746)
CASP2(348-452) [cytosol]
(R-HSA-2976745)
CASP2(2-452) [cytosol]
(R-HSA-622412)
0.63
5
UniProt:Q99750 MDFI
0.621
3
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