Reactome | Casp2 [cytosol]

Casp2 [cytosol]

Stable Identifier

R-MMU-2976746

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CASP2(170-325), P29594

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - TP53 Regulates Transcription of Cell Death Genes (Mus musculus)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Mus musculus)
        
        The PIDDosome activates CASP2 (Mus musculus)
        
        Casp2 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Death Receptor Signaling (Mus musculus)
  - p75 NTR receptor-mediated signalling (Mus musculus)
    - Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
      - NADE modulates death signalling (Mus musculus)
        
        p75NTR:NADE promotes caspase2/3 activation (Mus musculus)
        
        Active Caspases 2, 3 [cytosol] (Mus musculus)
        
        Active Caspase-2 heterotetramer [cytosol] (Mus musculus)
        
        Caspase-2 [cytosol] (Mus musculus)
        
        Casp2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P29594

Gene Names

Casp2

Reference Genes

BioGPS Gene:12366 Casp2

ENSEMBL:ENSMUSG00000029863

KEGG:mmu:12366 Casp2

Monarch:12366 Casp2

NCBI Gene:12366 Casp2

UCSC:P29594 Casp2

Reference Transcript

RefSeq:NM_007610.3 Casp2

Other Identifiers

10537728

12366

1448165_at

17457892

4377494

4378822

4487229

4562745

4582920

4627967

4697264

4729120

4788044

4791610

4898716

4910248

4939066

5028563

5041815

5053467

5126610

5137797

5176287

5323908

5348595

5423335

5445220

5448495

5534480

99049_at

A_51_P296448

A_55_P2721459

GE42472

GO:0001554

GO:0003407

GO:0004197

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0006508

GO:0006915

GO:0006974

GO:0008233

GO:0008234

GO:0008630

GO:0012501

GO:0016485

GO:0016787

GO:0019904

GO:0022414

GO:0030330

GO:0035234

GO:0042802

GO:0042981

GO:0043065

GO:0043066

GO:0043525

GO:0048856

GO:0071260

GO:0097190

GO:0097192

GO:1905369

GO:2001235

ILMN_1228387

ILMN_2637266

d28492_s_at

mMC024639

Participates

as an output of

The PIDDosome activates CASP2 (Mus musculus)

as a component of

Caspase-2 [cytosol] (Mus musculus)

Other forms of this molecule

Casp2 [cytosol]

Inferred From

CASP2(170-325) [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_031636.1

ENSEMBL

ENSMUSP00000031895, ENSMUST00000031895, ENSMUSG00000029863

PRO

P29594

MGI

97295

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