Reactome | The PIDDosome activates CASP2

The PIDDosome activates CASP2

Stable Identifier

R-HSA-6800797

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        The PIDDosome activates CASP2 (Homo sapiens)

General

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The PIDDosome promotes activation of CASP2 (caspase-2) by proteolytic cleavage, triggering apoptosis (Tinel and Tschopp 2004). The PIDDosome may also participate in the proteolytic activation of CASP3 and CASP7 (Berube et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15073321	The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress Tinel, A, Tschopp, J	Science	2004
16183742	Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD Hakem, R, Mak, TW, Yeh, WC, Ma, W, Boucher, LM, Benchimol, S, Berube, C, Wakeham, A, Salmena, L	Proc. Natl. Acad. Sci. U.S.A.	2005