The PIDDosome activates CASP2

Stable Identifier
R-HSA-6800797
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The PIDDosome promotes activation of CASP2 (caspase-2) by proteolytic cleavage, triggering apoptosis (Tinel and Tschopp 2004). The PIDDosome may also participate in the proteolytic activation of CASP3 and CASP7 (Berube et al. 2005).

Literature References
PubMed ID Title Journal Year
16183742 Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD

Berube, C, Boucher, LM, Ma, W, Wakeham, A, Salmena, L, Hakem, R, Yeh, WC, Mak, TW, Benchimol, S

Proc. Natl. Acad. Sci. U.S.A. 2005
15073321 The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

Tinel, A, Tschopp, J

Science 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity involved in apoptotic process of PIDDosome:CASP2(2-452) [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created