Reactome | MAP2K5 [cytosol]

MAP2K5 [cytosol]

Stable Identifier

R-HSA-198722

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MEK5, MPK5_HUMAN

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERK5 (Homo sapiens)
        
        ERK5 is activated (Homo sapiens)
        
        MAP2K5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13163 MAP2K5

Gene Names

MAP2K5, MEK5, MKK5, PRKMK5

Chain

chain:1-448

Reference Genes

BioGPS Gene:5607 MAP2K5

COSMIC (genes):MAP2K5 MAP2K5

CTD Gene:5607 MAP2K5

dbSNP Gene:5607 MAP2K5

ENSEMBL:ENSG00000137764 MAP2K5

ENSEMBL_homo_sapiens_GENE:ENSG00000137764.20 MAP2K5

HGNC:6845 MAP2K5

KEGG Gene (Homo sapiens):5607 MAP2K5

Monarch:5607 MAP2K5

NCBI Gene:5607 MAP2K5

OMIM:602520 MAP2K5

UCSC:Q13163 MAP2K5

Reference Transcript

Other Identifiers

11719312_a_at

16802326

1698_g_at

1722_at

204756_PM_at

204756_at

210482_PM_x_at

210482_x_at

211370_PM_s_at

211370_s_at

3599163

3599164

3599166

3599168

3599174

3599178

3599180

3599181

3599186

3599191

3599198

3599199

3599202

3599204

3599210

3599211

3599212

3599218

3599226

3599228

3599238

3599241

3599259

3599260

3599261

3599262

3599263

41230_at

513_at

5607

7984408

A_23_P84256

A_24_P356130

GE62483

GO:0000122

GO:0000165

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005819

GO:0005856

GO:0006351

GO:0006355

GO:0006468

GO:0007155

GO:0007165

GO:0007507

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030307

GO:0032088

GO:0032717

GO:0034115

GO:0034392

GO:0036211

GO:0043154

GO:0043226

GO:0043406

GO:0045944

GO:0046872

GO:0048009

GO:0048856

GO:0048870

GO:0050679

GO:0051247

GO:0051716

GO:0060761

GO:0070375

GO:0071363

GO:0071499

GO:0090051

GO:0106310

GO:0140096

GO:2000342

GO:2001240

HMNXSV003015106

ILMN_1718129

ILMN_2391891

PH_hs_0020481

TC15000625.hg

U25265_at

U71087_at

g1616778_3p_a_at

g4506100_3p_at

Cross References

RefSeq

NP_002748.1, NP_660143.1, NP_001193733.1

ZINC - World Drugs

MP2K5_HUMAN

Guide to Pharmacology - Targets

2066

OpenTargets

ENSG00000137764

ZINC - FDA approved

MP2K5_HUMAN

ZINC - Substances

MP2K5_HUMAN

ZINC target

Q13163

ZINC - Biogenic

MP2K5_HUMAN

PRO

Q13163

PDB

2O2V, 4IC7, 2NPT

ZINC - Investigational

MP2K5_HUMAN

HPA

ENSG00000137764-MAP2K5

GeneCards

Q13163

Ensembl

ENST00000354498, ENSG00000137764, ENST00000395476, ENSP00000178640, ENST00000178640, ENSP00000346493, ENSP00000378859

Pharos - Targets

Q13163

ZINC - Predictions - Purchasable

MP2K5_HUMAN

HMDB Protein

HMDBP08760

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13164 MAPK7	4	MAPK7 [nucleoplasm] (R-HSA-199961) MAPK7 [cytosol] (R-HSA-198754) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738)	0.863	8
UniProt:Q9Y2U5 M3K2			0.798	7
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.731	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.669	4
UniProt:Q8N448 LNX2			0.668	3
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.666	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.643	4
UniProt:Q96NT3-2 GUCD1			0.556	3
UniProt:Q9H596 DUS21			0.556	3
UniProt:Q9BUY5 ZNF426	1	ZNF426 [nucleoplasm] (R-HSA-1247530)	0.556	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q3SXR2 CC036			0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:Q9H8K7 PAAT			0.527	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	3