Reactome | Ub-C114-UBE2C [cytosol]

Ub-C114-UBE2C [cytosol]

Stable Identifier

R-HSA-8864184

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UbcH10, UbcX, E2-C

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [cytosol] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Homo sapiens)
        
        Ub-C114-UBE2C [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00762 UBE2C

Gene Names

UBE2C, UBCH10

Chain

initiator methionine:, chain:2-179

Reference Genes

BioGPS Gene:11065 UBE2C

COSMIC (genes):UBE2C UBE2C

CTD Gene:11065 UBE2C

dbSNP Gene:11065 UBE2C

ENSEMBL:ENSG00000175063 UBE2C

HGNC:15937 UBE2C

KEGG:hsa:11065 UBE2C

Monarch:11065 UBE2C

NCBI Gene:11065 UBE2C

OMIM:605574 UBE2C

UCSC:O00762 UBE2C

Reference Transcript

Other Identifiers

11065

11724328_a_at

11733695_a_at

11733696_x_at

11733702_x_at

1651_at

16914315

202954_PM_at

202954_at

3587064

3887050

3887051

3887052

3887053

3887054

3887058

3887059

3887061

3887062

3887063

3887064

3887066

3887067

3887068

8063043

A_14_P116706

A_24_P297539

GE59386

GO:0000151

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005680

GO:0005829

GO:0005886

GO:0006511

GO:0010458

GO:0010994

GO:0016567

GO:0016740

GO:0019787

GO:0030071

GO:0030163

GO:0031145

GO:0031536

GO:0032446

GO:0043161

GO:0043226

GO:0044389

GO:0045842

GO:0051301

GO:0061630

GO:0061631

GO:0065003

GO:0070936

GO:0070979

GO:0140096

GO:1904668

HMNXSV003018234

ILMN_1714730

ILMN_2265654

ILMN_2301083

PH_hs_0005126

PH_hs_0031411

TC20000357.hg

U73379_at

g5902145_3p_at

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Homo sapiens)

Other forms of this molecule

UBE2C [cytosol]

UBE2C [nucleoplasm]

Ub-C114-UBE2C [nucleoplasm]

Inferred To

UBE2C [cytosol] (Bos taurus)

UBE2C [cytosol] (Canis familiaris)

Ube2c [cytosol] (Mus musculus)

Ube2c [cytosol] (Rattus norvegicus)

UBE2U [cytosol] (Gallus gallus)

ubc11 [cytosol] (Schizosaccharomyces pombe)

vih [cytosol] (Drosophila melanogaster)

UBC11 [cytosol] (Saccharomyces cerevisiae)

ube2c [cytosol] (Dictyostelium discoideum)

Ub-C114-UBE2C [cytosol] (Sus scrofa)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 114

Coordinate

114

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_001268671.1, NP_861516.1, NP_001268670.1, NP_861515.1, NP_861517.1, NP_008950.1

OpenTargets

ENSG00000175063

ENSEMBL

ENSP00000348838, ENSP00000361649, ENSP00000333975, ENST00000352551, ENST00000335046, ENSP00000335674, ENST00000356455, ENST00000372568

HPA

ENSG00000175063-UBE2C

PRO

O00762

Pharos - Targets

O00762

PDB

4YII, 5A31, 8TAR, 5L9U, 1I7K, 5KHR, 8TAU

HMDB Protein

HMDBP00649

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13164 MAPK7	4	p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) MAPK7 [cytosol] (R-HSA-198754) MAPK7 [nucleoplasm] (R-HSA-199961)	0.556	3