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NFKB1(1-433):RELA [cytosol]
Stable Identifier
R-HSA-194043
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
p50/p65 complex, NF-kB complex
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Activated IKK phosphorylates I-kappaB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Homo sapiens)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Ubiquitinated IkB is degraded (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Homo sapiens)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Regulated proteolysis of p75NTR (Homo sapiens)
p75NTR ICD signals to NF-kB (Homo sapiens)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)
IkB(alpha):NF-kB complex [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)
NFKB1(1-433):RELA [cytosol] (Homo sapiens)
Participants
components
NFKB1(1-433) [cytosol] (Homo sapiens)
RELA [cytosol] (Homo sapiens)
Participant Of
hasComponent
IkB(alpha):NF-kB complex [cytosol]
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol]
NF-kappaB p50:p65:IKB [cytosol]
NF-kappaB p50:p65:p-IKB [cytosol]
NF-kappaB p50:p65:ub-p-IKB [cytosol]
NF-kB:p75NTR ICD:TRAF6 [cytosol]
p-S32,36-IkB-alpha:NF-kB complex [cytosol]
hasMember
NF-kappaB p50,p65,c-Rel dimer [cytosol]
output
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
IKKbeta phosphorylates IkB causing NF-kB to dissociate
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
input
NF-kB migrates to the nucleus and turns on transcription
NFKB1:RELA translocates from the cytosol to the nucleus
p75NTR ICD signals to NF-kB
Inferred To
NFKB1(1-433):RELA [cytosol] (Bos taurus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Sus scrofa)
NFKB1(1-433):RELA [cytosol] (Xenopus tropicalis)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
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