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NFKB1(1-433), NFKB2(1-454):RELA [cytosol]
Stable Identifier
R-DME-168155
Type
Complex
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to mechanical stimuli (Drosophila melanogaster)
Response of endothelial cells to shear stress (Drosophila melanogaster)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Drosophila melanogaster)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Downstream signaling events of B Cell Receptor (BCR) (Drosophila melanogaster)
Activation of NF-kappaB in B cells (Drosophila melanogaster)
Activated IKK phosphorylates I-kappaB (Drosophila melanogaster)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Drosophila melanogaster)
NF-kappaB p50:p65:IKB [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Drosophila melanogaster)
NF-kappaB p50:p65:p-IKB [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappaB translocates from the cytosol to the nucleus (Drosophila melanogaster)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Ubiquitinated IkB is degraded (Drosophila melanogaster)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Drosophila melanogaster)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-1 family signaling (Drosophila melanogaster)
Interleukin-1 signaling (Drosophila melanogaster)
NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Cytosolic sensors of pathogen-associated DNA (Drosophila melanogaster)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Drosophila melanogaster)
NFkB complex translocates from the cytosol to the nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
ZBP1(DAI) mediated induction of type I IFNs (Drosophila melanogaster)
RIP-mediated NFkB activation via ZBP1 (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB complex translocates from the cytosol to the nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Drosophila melanogaster)
TRAF6 mediated NF-kB activation (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated NF-kB activation (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Toll-like Receptor Cascades (Drosophila melanogaster)
Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
MyD88-independent TLR4 cascade (Drosophila melanogaster)
TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signaling (Drosophila melanogaster)
p75 NTR receptor-mediated signalling (Drosophila melanogaster)
p75NTR signals via NF-kB (Drosophila melanogaster)
NF-kB is activated and signals survival (Drosophila melanogaster)
NF-kB migrates to the nucleus and turns on transcription (Drosophila melanogaster)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Homologues of RELA [cytosol]
(Drosophila melanogaster)
Rel [cytosol]
(Drosophila melanogaster)
Participates
as an input of
NFkB complex translocates from the cytosol to the nucleus (Drosophila melanogaster)
NF-kB migrates to the nucleus and turns on transcription (Drosophila melanogaster)
NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)
NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)
NF-kappa-B inhibitor binds NF-kappa-B complex (Drosophila melanogaster)
as an output of
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Drosophila melanogaster)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Drosophila melanogaster)
as a component of
NF-kappaB p50:p65:IKB [cytosol] (Drosophila melanogaster)
NF-kappaB p50:p65:p-IKB [cytosol] (Drosophila melanogaster)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Drosophila melanogaster)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Drosophila melanogaster)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Drosophila melanogaster)
NFkB inhibitor:NFkB complex [cytosol] (Drosophila melanogaster)
as a member of
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Drosophila melanogaster)
Inferred From
NFKB1(1-433):RELA [cytosol]
(Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [cytosol]
(Homo sapiens)
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