Reactome | 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex

26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex

Stable Identifier

R-HSA-5607724

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex

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Following ubiquitination NF-kappa-B inhibitor alpha (NFKBIA or IκBα) is rapidly degraded by 26S-proteasome, allowing NF-kB to translocate into the nucleus where it activates gene transcription (Spencer et al. 1999).

Severe acute respiratory syndrome coronavirus (SARS-CoV) 1a-encoded papain-like protease (PLPro or nsp3) was found to cleave Lys48-linked polyUb chains of NFKBIA (IκBα) (Békés M et al. 2016;Ratia K et al. 2014) suggesting an inhibitory effect of SARS-CoV-1 nsp3 on 26S proteasome-dependent degradation of NFKBIA.

Literature References

PubMed ID	Title	Journal	Year
9362451	The carboxy-terminus of I kappaB alpha determines susceptibility to degradation by the catalytic core of the proteasome Desterro, MJ, Kroll, M, Arenzana-Seisdedos, F, Marin, A, Thomas, D, Virelizier, JL, Conconi, M, Rodriguez, MS, Hay, RT, Friguet, B	Oncogene	1997