Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex

Stable Identifier
Reaction [omitted]
Homo sapiens
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Ubiquitinated IKBA is degraded by the proteasome complex.

Literature References
PubMed ID Title Journal Year
7628694 Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

Chen, Z, Hagler, J, Palombella, VJ, Melandri, F, Scherer, D, Ballard, D, Maniatis, T

Genes Dev 1995
10514433 Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha

Hattori, K, Hatakeyama, S, Shirane, M, Matsumoto, M, Nakayama, K

J Biol Chem 1999
9990853 Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

Spencer, E, Jiang, J, Chen, ZJ

Genes Dev 1999
10075690 Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP

Kroll, M, Margottin, F, Kohl, A, Renard, P, Durand, H, Concordet, JP, Bachelerie, F, Arenzana-Seisdedos, F, Benarous, R

J Biol Chem 1999
10918611 SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4

Strack, P, Caligiuri, M, Pelletier, M, Boisclair, M, Theodoras, A, Beer-Romero, P, Glass, S, Parsons, T, Copeland, RA, Auger, KR, Benfield, P, Brizuela, L, Rolfe, M

Oncogene 2000
9859996 Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Yaron, A, Hatzubai, A, Davis, M, Lavon, I, Amit, S, Manning, AM, Andersen, JS, Mann, M, Mercurio, F, Ben-Neriah, Y

Nature 1998
Participant Of
Catalyst Activity
Catalyst Activity
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Orthologous Events
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