Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex

Stable Identifier
R-HSA-209061
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ubiquitinated IKBA is degraded by the proteasome complex.

Literature References
PubMed ID Title Journal Year
7628694 Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

Chen, Z, Hagler, J, Palombella, VJ, Melandri, F, Scherer, D, Ballard, D, Maniatis, T

Genes Dev 1995
10514433 Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha

Hattori, K, Hatakeyama, S, Shirane, M, Matsumoto, M, Nakayama, K

J Biol Chem 1999
9990853 Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

Spencer, E, Jiang, J, Chen, ZJ

Genes Dev 1999
10075690 Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP

Kroll, M, Margottin, F, Kohl, A, Renard, P, Durand, H, Concordet, JP, Bachelerie, F, Arenzana-Seisdedos, F, Benarous, R

J Biol Chem 1999
10918611 SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4

Strack, P, Caligiuri, M, Pelletier, M, Boisclair, M, Theodoras, A, Beer-Romero, P, Glass, S, Parsons, T, Copeland, RA, Auger, KR, Benfield, P, Brizuela, L, Rolfe, M

Oncogene 2000
9859996 Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Yaron, A, Hatzubai, A, Davis, M, Lavon, I, Amit, S, Manning, AM, Andersen, JS, Mann, M, Mercurio, F, Ben-Neriah, Y

Nature 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created