IKKbeta phosphorylates IkB causing NF-kB to dissociate

Stable Identifier
R-HSA-193705
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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IkB is an inhibitory protein that sequesters NF-kB in the cytoplasm, by masking a nuclear localization signal, located just at the C-terminal end in each of the NF-kB subunits. A key event in NF-kB activation involves phosphorylation of IkB by an IkB kinase (IKK). NGF stimulates the activity of the IkB kinase IKK-beta, and, possibly, IKK-alpha as well. Once IkB is phosphorylated, the IkB:NF-kB complex dissociates.

Literature References
PubMed ID Title Journal Year
9252186 A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

DiDonato, JA, Hayakawa, M, Rothwarf, DM, Zandi, E, Karin, M

Nature 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created