NF-kB migrates to the nucleus and turns on transcription

Stable Identifier
R-HSA-193691
Type
Reaction [transition]
Species
Homo sapiens
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Once dissociated from IkB, NF-kB moves to the nucleus. Once in the nucleus, NF-kB binds DNA at promoters of target genes. This entails transcription of several genes including the two HLH transcriptional regulators HES1 and HES5. HES1 and HES5 transcription can also be activated via NOTCH signalling. Increased production of HES1 and HES5 reduces the number of primary dendrites and promotes dendrite elongation.

Literature References
PubMed ID Title Journal Year
15496460 NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch

Salama-Cohen, P, Arévalo, MA, Meier, J, Grantyn, R, Rodriguez-Tébar, A

Mol Biol Cell 2005
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