The p75NTR ICD has the potential to bind many intracellular proteins, including TRAF6, SC1, NADE, NRAGE, and RHOA. It may bring these proteins to function in different cellular compartments. p75NTR ICD was shown to activate NF-kB via TRAF6.
Kanning, KC, Hudson, M, Amieux, PS, Wiley, JC, Bothwell, M, Schecterson, LC
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