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NFKB1(1-433):RELA [cytosol]
Stable Identifier
R-RNO-194043
Type
Complex
Species
Rattus norvegicus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Rattus norvegicus)
Cell junction organization (Rattus norvegicus)
Cell-cell junction organization (Rattus norvegicus)
Adherens junctions interactions (Rattus norvegicus)
Activation of STAT3 by cadherin engagement (Rattus norvegicus)
RAC1, CDC42 activate NFκB (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Rattus norvegicus)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Rattus norvegicus)
IkB(alpha):NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Downstream signaling events of B Cell Receptor (BCR) (Rattus norvegicus)
Activation of NF-kappaB in B cells (Rattus norvegicus)
Activated IKK phosphorylates I-kappaB (Rattus norvegicus)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Rattus norvegicus)
NF-kappaB p50:p65:IKB [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Rattus norvegicus)
NF-kappaB p50:p65:p-IKB [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NF-kappaB translocates from the cytosol to the nucleus (Rattus norvegicus)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Rattus norvegicus)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Rattus norvegicus)
NF-kappaB p50:p65:p-IKB [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Rattus norvegicus)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Rattus norvegicus)
NF-kappaB p50:p65:p-IKB [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
SCF-beta-TrCP ubiquitinylates IkB (Rattus norvegicus)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Rattus norvegicus)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Rattus norvegicus)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Rattus norvegicus)
NF-kappaB p50:p65:p-IKB [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
Ubiquitinated IkB is degraded (Rattus norvegicus)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Rattus norvegicus)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Rattus norvegicus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NFKB1:RELA translocates from the cytosol to the nucleus (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Rattus norvegicus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Rattus norvegicus)
IkB(alpha):NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
NFKB1:RELA translocates from the cytosol to the nucleus (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Rattus norvegicus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NFKB1:RELA translocates from the cytosol to the nucleus (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Rattus norvegicus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Rattus norvegicus)
IkB(alpha):NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated NF-kB activation (Rattus norvegicus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Rattus norvegicus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NFKB1:RELA translocates from the cytosol to the nucleus (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Rattus norvegicus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Rattus norvegicus)
IkB(alpha):NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Regulated proteolysis of p75NTR (Rattus norvegicus)
p75NTR ICD signals to NF-kB (Rattus norvegicus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
NF-kB is activated and signals survival (Rattus norvegicus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Rattus norvegicus)
IkB(alpha):NF-kB complex [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
NF-kB migrates to the nucleus and turns on transcription (Rattus norvegicus)
NFKB1(1-433):RELA [cytosol] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Nfkb1 [cytosol]
(Rattus norvegicus)
Rela [cytosol]
(Rattus norvegicus)
Participates
as a component of
NF-kappaB p50:p65:IKB [cytosol] (Rattus norvegicus)
NF-kappaB p50:p65:p-IKB [cytosol] (Rattus norvegicus)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Rattus norvegicus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Rattus norvegicus)
IkB(alpha):NF-kB complex [cytosol] (Rattus norvegicus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Rattus norvegicus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Rattus norvegicus)
as a member of
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Rattus norvegicus)
as an input of
NF-kB migrates to the nucleus and turns on transcription (Rattus norvegicus)
p75NTR ICD signals to NF-kB (Rattus norvegicus)
NFKB1:RELA translocates from the cytosol to the nucleus (Rattus norvegicus)
RAC1, CDC42 activate NFκB (Rattus norvegicus)
as an output of
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Rattus norvegicus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Rattus norvegicus)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Rattus norvegicus)
Inferred From
NFKB1(1-433):RELA [cytosol]
(Homo sapiens)
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Reactome
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