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NFKB1(1-433):RELA [cytosol]
Stable Identifier
R-MMU-194043
Type
Complex
Species
Mus musculus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Mus musculus)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Downstream signaling events of B Cell Receptor (BCR) (Mus musculus)
Activation of NF-kappaB in B cells (Mus musculus)
Activated IKK phosphorylates I-kappaB (Mus musculus)
NF-kappa-B p50,p65,c-Rel:IKB [cytosol] (Mus musculus)
NF-kappaB p50:p65:IKB [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Mus musculus)
NF-kappaB p50:p65:p-IKB [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NF-kappaB translocates from the cytosol to the nucleus (Mus musculus)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Mus musculus)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Mus musculus)
NF-kappaB p50:p65:p-IKB [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Mus musculus)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Mus musculus)
NF-kappaB p50:p65:p-IKB [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Mus musculus)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Mus musculus)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Mus musculus)
NF-kappaB p50:p65:p-IKB [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
Ubiquitinated IkB is degraded (Mus musculus)
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NF-kappaB p50,p65,c-Rel:ub-p-IKB [cytosol] (Mus musculus)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
TCR signaling (Mus musculus)
Downstream TCR signaling (Mus musculus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-1 family signaling (Mus musculus)
Interleukin-1 signaling (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated NF-kB activation (Mus musculus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Regulated proteolysis of p75NTR (Mus musculus)
p75NTR ICD signals to NF-kB (Mus musculus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
p75NTR signals via NF-kB (Mus musculus)
NF-kB is activated and signals survival (Mus musculus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
NF-kB migrates to the nucleus and turns on transcription (Mus musculus)
NFKB1(1-433):RELA [cytosol] (Mus musculus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Nfkb1 [cytosol]
(Mus musculus)
Rela [cytosol]
(Mus musculus)
Participates
as an output of
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Mus musculus)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Mus musculus)
as a component of
NF-kappaB p50:p65:IKB [cytosol] (Mus musculus)
NF-kappaB p50:p65:p-IKB [cytosol] (Mus musculus)
NF-kappaB p50:p65:ub-p-IKB [cytosol] (Mus musculus)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Mus musculus)
K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex [cytosol] (Mus musculus)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Mus musculus)
IkB(alpha):NF-kB complex [cytosol] (Mus musculus)
as a member of
NF-kappaB p50,p65,c-Rel dimer [cytosol] (Mus musculus)
as an input of
NF-kB migrates to the nucleus and turns on transcription (Mus musculus)
p75NTR ICD signals to NF-kB (Mus musculus)
NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)
Inferred From
NFKB1(1-433):RELA [cytosol]
(Homo sapiens)
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