Synthesis of IP2, IP, and Ins in the cytosol

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R-HSA-1855183
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Pathway
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Homo sapiens
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Inositol phosphates IP2, IP and the six-carbon cyclic alcohol inositol (Ins) are produced by various phosphatases and the inositol-3-phosphate synthase 1 (ISYNA1) (Ju et al. 2004, Ohnishi et al. 2007, Irvine & Schell 2001, Bunney & Katan 2010).

Literature References
PubMed ID Title Journal Year
15024000 Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast

Greenberg, ML, Shamir, A, Agam, G, Ju, S, Shaltiel, G

J Biol Chem 2004
17068342 Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1

Seo, KC, Sato, Y, Ohba, H, Ohnishi, T, Chung, SK, Furuichi, T, Im, J, Yoshikawa, T, Iwayama, Y

J Biol Chem 2007
11331907 Back in the water: the return of the inositol phosphates

Schell, MJ, Irvine, RF

Nat Rev Mol Cell Biol 2001
20414202 Phosphoinositide signalling in cancer: beyond PI3K and PTEN

Bunney, TD, Katan, M

Nat Rev Cancer 2010
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