MIOX oxidises Ins to GlcA

Stable Identifier
R-HSA-5678327
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Inositol oxidase (MIOX) catalyses the oxidation of inositol (Ins) to glucuronic acid (GlcA). MIOX binds two Fe2+ ions as cofactor (Arner et al. 2004, Thorsell et al. 2008).

Literature References
PubMed ID Title Journal Year
15504367 Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney

Arner, RJ, Prabhu, KS, Reddy, CC

Biochem. Biophys. Res. Commun. 2004
18364358 Structural and biophysical characterization of human myo-inositol oxygenase

Thorsell, AG, Persson, C, Voevodskaya, N, Busam, RD, Hammarström, M, Gräslund, S, Gräslund, A, Hallberg, BM

J. Biol. Chem. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol oxygenase activity of MIOX:2xFe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!