Reactome | ANAPC15 [cytosol]

ANAPC15 [cytosol]

Stable Identifier

R-HSA-6805140

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Anaphase-promoting complex subunit 15, APC15_HUMAN

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Binding of the MCC complex to the APC/C complex (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        Association of Securin with Cdc20:APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Securin (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Cyclin B (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Homo sapiens)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
        
        Association of Securin with Cdc20:APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Securin (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
        
        APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
        
        Association of Nek2A with MCC:APC/C (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Nek2A (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Multiubiquitination of Nek2A (Homo sapiens)
        
        Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
        
        Association of Cyclin A with the APC/C (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Degradation multiubiquitinated Cyclin A (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Homo sapiens)
        
        Association of Cdh1 with the APC/C (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        Dissociation of Cdc20 from APC/C complex (Homo sapiens)
        
        CDC20:p-APC/C [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Binding of the MCC complex to the APC/C complex (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
        
        ANAPC15 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P60006 ANAPC15

Gene Names

ANAPC15, C11orf51, HSPC020

Chain

chain:1-121

Reference Genes

BioGPS Gene:25906 ANAPC15

COSMIC (genes):ANAPC15 ANAPC15

CTD Gene:25906 ANAPC15

dbSNP Gene:25906 ANAPC15

ENSEMBL:ENSG00000110200 ANAPC15

HGNC:24531 ANAPC15

KEGG:hsa:25906 ANAPC15

Monarch:25906 ANAPC15

NCBI Gene:25906 ANAPC15

OMIM:614717 ANAPC15

UCSC:P60006 ANAPC15

Reference Transcript

Other Identifiers

11726077_a_at

16741659

204218_PM_at

204218_at

25906

3380997

3380998

3380999

3381000

3381001

3381002

3381003

3381004

3381005

3381006

3381007

3381008

3381009

3381010

3381011

3381012

35715_at

7950128

A_24_P244410

GE56325

GO:0005515

GO:0005654

GO:0005680

GO:0005829

GO:0007346

GO:0030163

GO:0031145

GO:0051301

GO:0051445

GO:0070936

GO:0070979

GO:0090266

GO:0141198

HMNXSV003041437

ILMN_1726104

PH_hs_0002976

TC11002054.hg

g7661621_3p_at

Participates

as a component of

phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)

Other forms of this molecule

ANAPC15 [nucleoplasm]

Inferred To

anapc15 [cytosol] (Xenopus tropicalis)

ANAPC15 [cytosol] (Bos taurus)

ANAPC15 [cytosol] (Canis familiaris)

ANAPC15 [cytosol] (Gallus gallus)

ANAPC15 [cytosol] (Sus scrofa)

Ghost homologue of ANAPC15 [cytosol] (Caenorhabditis elegans)

Ghost homologue of ANAPC15 [cytosol] (Dictyostelium discoideum)

Ghost homologue of ANAPC15 [cytosol] (Drosophila melanogaster)

Anapc15 [cytosol] (Mus musculus)

Anapc15 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001265423.1, NP_001265421.1, NP_001265422.1, NP_001265418.1, NP_001265420.1, NP_001265417.1, NP_001265416.1, NP_001265415.1, NP_001265414.1, NP_001265419.1, NP_054761.1, XP_016872986.1, XP_016872985.1

OpenTargets

ENSG00000110200

ENSEMBL

ENSG00000110200, ENSP00000440002, ENSP00000443911, ENST00000545680, ENSP00000443645, ENSP00000227618, ENST00000227618, ENST00000538919, ENSP00000440983, ENSP00000446412, ENST00000542531, ENST00000543587, ENST00000538393, ENST00000545944, ENSP00000446383, ENSP00000443383, ENST00000535503, ENST00000535234, ENSP00000439403

HPA

ENSG00000110200-ANAPC15

GeneCards

ANAPC15

PRO

P60006

Pharos - Targets

P60006

PDB

5LCW, 5A31, 6TM5, 6Q6G, 6Q6H, 4UI9, 5L9T, 5L9U, 6TNT, 8TAU, 6TLJ, 8PKP, 8TAR, 5G05, 5G04, 9GAW

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.527	2
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [cytosol] (R-HSA-177324) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) FBXO5 [nucleoplasm] (R-HSA-174060) p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-FBXO5 [nucleoplasm] (R-HSA-163049)	0.527	2
UniProt:P51955 NEK2	1	NEK2 [cytosol] (R-HSA-177329)	0.527	2

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