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ANAPC15 [nucleoplasm]
Stable Identifier
R-HSA-6805136
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Anaphase-promoting complex subunit 15, APC15_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
Phosphorylation of the APC/C (Homo sapiens)
Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Free APC/C phosphorylated by Plk1 (Homo sapiens)
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Multiubiquitination of APC/C-associated Cdh1 (Homo sapiens)
multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Homo sapiens)
Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Homo sapiens)
phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
ANAPC15 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60006 ANAPC15
Gene Names
ANAPC15, C11orf51, HSPC020
Chain
chain:1-121
Reference Genes
BioGPS Gene:25906 ANAPC15
COSMIC (genes):ANAPC15 ANAPC15
CTD Gene:25906 ANAPC15
dbSNP Gene:25906 ANAPC15
ENSEMBL:ENSG00000110200 ANAPC15
HGNC:24531 ANAPC15
KEGG:hsa:25906 ANAPC15
Monarch:25906 ANAPC15
NCBI Gene:25906 ANAPC15
OMIM:614717 ANAPC15
UCSC:P60006 ANAPC15
Reference Transcript
RefSeq:NM_001278486.1 ANAPC15
RefSeq:NM_001278494.1 ANAPC15
RefSeq:NM_001278487.1 ANAPC15
RefSeq:XM_017017497.1 ANAPC15
RefSeq:NM_001278490.1 ANAPC15
RefSeq:NM_001278488.1 ANAPC15
RefSeq:NM_001278489.1 ANAPC15
RefSeq:XM_017017496.1 ANAPC15
RefSeq:NM_014042.2 ANAPC15
RefSeq:NM_001278492.1 ANAPC15
RefSeq:NM_001278493.1 ANAPC15
RefSeq:NM_001278485.1 ANAPC15
RefSeq:NM_001278491.1 ANAPC15
Other Identifiers
11726077_a_at
16741659
204218_PM_at
204218_at
25906
3380997
3380998
3380999
3381000
3381001
3381002
3381003
3381004
3381005
3381006
3381007
3381008
3381009
3381010
3381011
3381012
35715_at
7950128
A_24_P244410
GE56325
GO:0005515
GO:0005654
GO:0005680
GO:0005829
GO:0007346
GO:0030163
GO:0031145
GO:0051301
GO:0051445
GO:0070936
GO:0070979
GO:0090266
GO:0141198
HMNXSV003041437
ILMN_1726104
PH_hs_0002976
TC11002054.hg
g7661621_3p_at
Participates
as a component of
anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
ANAPC15 [cytosol]
Inferred To
ANAPC15 [nucleoplasm]
(Bos taurus)
ANAPC15 [nucleoplasm]
(Canis familiaris)
ANAPC15 [nucleoplasm]
(Gallus gallus)
ANAPC15 [nucleoplasm]
(Sus scrofa)
Ghost homologue of ANAPC15 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of ANAPC15 [nucleoplasm]
(Drosophila melanogaster)
anapc15 [nucleoplasm]
(Xenopus tropicalis)
Anapc15 [nucleoplasm]
(Mus musculus)
Anapc15 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
XP_016872985.1
,
XP_016872986.1
,
NP_001265420.1
,
NP_001265422.1
,
NP_054761.1
,
NP_001265417.1
,
NP_001265421.1
,
NP_001265423.1
,
NP_001265418.1
,
NP_001265419.1
,
NP_001265414.1
,
NP_001265416.1
,
NP_001265415.1
OpenTargets
ENSG00000110200
ENSEMBL
ENST00000545680
,
ENSP00000439403
,
ENST00000227618
,
ENSP00000227618
,
ENSP00000443383
,
ENSP00000440983
,
ENSP00000446383
,
ENST00000538393
,
ENSP00000440002
,
ENST00000535503
,
ENST00000535234
,
ENSP00000446412
,
ENSP00000443911
,
ENST00000545944
,
ENSP00000443645
,
ENST00000538919
,
ENST00000542531
,
ENST00000543587
HPA
ENSG00000110200-ANAPC15
PRO
P60006
Pharos - Targets
P60006
PDB
8TAR
,
7QE7
,
6TLJ
,
8S4G
,
5G05
,
5G04
,
8PKP
,
8TAU
,
5LCW
,
5A31
,
4UI9
,
6TNT
,
6TM5
,
5L9U
,
6Q6G
,
5L9T
,
6Q6H
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.527
2
UniProt:P51955 NEK2
1
NEK2 [cytosol]
(R-HSA-177329)
0.527
2
UniProt:Q9UKT4 FBXO5
6
p-S182-FBXO5 [cytosol]
(R-HSA-177324)
p-S145,S149-FBXO5 [cytosol]
(R-HSA-174207)
FBXO5 [nucleoplasm]
(R-HSA-174060)
p-S182-FBXO5 [nucleoplasm]
(R-HSA-176447)
p-S145,S149-FBXO5 [nucleoplasm]
(R-HSA-174220)
p-FBXO5 [nucleoplasm]
(R-HSA-163049)
0.527
2
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