Reactome | Association of Nek2A with MCC:APC/C

Association of Nek2A with MCC:APC/C

Stable Identifier

R-HSA-179410

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
        
        APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
        
        Association of Nek2A with MCC:APC/C (Homo sapiens)

General

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Nek2A does not appear to be recruited to the APC/C by Cdc20 but rather binds directly to the APC/C in an interaction involving the NEK2A C-terminal methionine–arginine (MR) dipeptide tail (Hayes et al., 2006).

Literature References

PubMed ID	Title	Journal	Year
11742988	APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box Fry, AM, Bacchieri, R, Yamano, H, Wattam, SL, Hames, RS	EMBO J	2001
16648845	Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C Fry, AM, Mao, G, Kimata, Y, Hayes, MJ, Lindon, C, Yamano, H, Wattam, SL	Nat Cell Biol	2006