Reactome | Association of Nek2A with MCC:APC/C

Association of Nek2A with MCC:APC/C

Stable Identifier

R-HSA-179410

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
        
        APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
        
        Association of Nek2A with MCC:APC/C (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Nek2A does not appear to be recruited to the APC/C by Cdc20 but rather binds directly to the APC/C in an interaction involving the NEK2A C-terminal methionine–arginine (MR) dipeptide tail (Hayes et al., 2006).

Literature References

PubMed ID	Title	Journal	Year
11742988	APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box Fry, AM, Bacchieri, R, Yamano, H, Wattam, SL, Hames, RS	EMBO J	2001
16648845	Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C Fry, AM, Mao, G, Kimata, Y, Hayes, MJ, Lindon, C, Yamano, H, Wattam, SL	Nat Cell Biol	2006