Reactome | nek2 [cytosol]

nek2 [cytosol]

Stable Identifier

R-DRE-177329

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

NEK2, Q7ZUN2

Locations in the PathwayBrowser

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Cell Cycle (Danio rerio)

- Cell Cycle, Mitotic (Danio rerio)
  - M Phase (Danio rerio)
    - Mitotic Prometaphase (Danio rerio)
      - Recruitment of NuMA to mitotic centrosomes (Danio rerio)
        
        Translocation of NuMA to the centrosomes (Danio rerio)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Danio rerio)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Danio rerio)
        
        centrosome [cytosol] (Danio rerio)
        
        nek2 [cytosol] (Danio rerio)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Danio rerio)
        
        centrosome [cytosol] (Danio rerio)
        
        nek2 [cytosol] (Danio rerio)
  - Regulation of mitotic cell cycle (Danio rerio)
    - APC/C-mediated degradation of cell cycle proteins (Danio rerio)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Danio rerio)
        
        APC-Cdc20 mediated degradation of Nek2A (Danio rerio)
        
        Association of Nek2A with MCC:APC/C (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        nek2 [cytosol] (Danio rerio)
        
        nek2 [cytosol] (Danio rerio)
        
        Degradation of multiubiquitinated Nek2A (Danio rerio)
        
        Multiubiquitinated Nek2A [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        nek2 [cytosol] (Danio rerio)
        
        Multiubiquitination of Nek2A (Danio rerio)
        
        Multiubiquitinated Nek2A [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        nek2 [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        nek2 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7ZUN2

Gene Names

nek2

Reference Genes

BioGPS Gene:394025 nek2

ENSEMBL:ENSDARG00000005619

KEGG:dre:394025 nek2

Monarch:394025 nek2

NCBI Gene:394025 nek2

UCSC:Q7ZUN2 nek2

Reference Transcript

RefSeq:NM_201050.1 nek2

Other Identifiers

13094801

13094813

394025

A_15_P102113

A_15_P139846

A_15_P497237

CUST_864_PI428451958

DRER00230

DRER50565

Dr.10580.1.S1_at

ENSDART00000003248

ENSDART00000003248_1

ENSDART00000003248_2

GO:0003824

GO:0004672

GO:0005524

GO:0006468

GO:0016740

GO:0140096

GT_Spec_NM_201050.1_337206

LOLS15775

MADDr01005148

OTTDART00000004941

OTTDART00000004952

XM_697346

Participates

as an input of

Association of Nek2A with MCC:APC/C (Danio rerio)

as a component of

Inferred From

NEK2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_957344.1

ENSEMBL

ENSDART00000188006, ENSDARG00000005619, ENSDARP00000020452, ENSDART00000003248, ENSDARP00000149828

ZFIN

ZDB-GENE-040426-752

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