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C3b [extracellular region]
Stable Identifier
R-HSA-166832
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Activation of C3 and C5 (Homo sapiens)
Activation of C5 (Homo sapiens)
C5 convertases [plasma membrane] (Homo sapiens)
C3b:Bb:C3b:Properdin [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cleavage of C3 by C3 convertases (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Formation of classic pathway C5 convertase (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Alternative complement activation (Homo sapiens)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
C3b binds to cell surface (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Factor B binds to surface-associated C3b (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:CFB [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Factor D cleaves C3b-bound Factor B (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:CFB [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Formation of alternative pathway C5 convertase (Homo sapiens)
C3b:Bb:C3b:Properdin [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Properdin stabilizes C3b:Bb bound to cell surfaces (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
C3 convertases spontaneously dissociate (Homo sapiens)
C3 convertases [plasma membrane] (Homo sapiens)
C4b:C2a:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CD46 binds C3b (Homo sapiens)
CD46:Cell surface:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CD55 (DAF) binds C3bBb, C4bC2a (Homo sapiens)
C4bC2a, C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CD55:C3 convertase complexes [plasma membrane] (Homo sapiens)
CD55:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)
CD55:C3 convertase complexes [plasma membrane] (Homo sapiens)
CD55:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CD55:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CFHR dimers bind C3b (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:C3b:CFHR dimers [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CR1 binds C3bBb/C4bC2a (Homo sapiens)
C4bC2a, C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Homo sapiens)
CR1:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Homo sapiens)
CD46:Cell surface:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CR1:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Homo sapiens)
CD46:Cell surface:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CR1:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Complement factor I binds to extracellular Factor H:C3b (Homo sapiens)
CFH:C3b [extracellular region] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CFI:CFH:C3b [extracellular region] (Homo sapiens)
CFH:C3b [extracellular region] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Complement factor I binds to membrane-associated Factor H:C3b (Homo sapiens)
CFI:CFH,FHR3:C3b [plasma membrane] (Homo sapiens)
Cell surface:FH,FHR3:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:FH,FHR3:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Displacement of C2a/Bb by CR1 (Homo sapiens)
CR1:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Homo sapiens)
CR1:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Factor H binds to C3b (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CFH:C3b [extracellular region] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Factor H binds to C3bBb (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Factor H binds to membrane-associated C3b (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:FH,FHR3:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Factor H displaces Bb (Homo sapiens)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Homo sapiens)
Cell surface:C3b:Bb [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Cell surface:FH,FHR3:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Factor I inactivates Factor H-boundC3b (Homo sapiens)
CFI:CFH,FHR3:C3b [plasma membrane] (Homo sapiens)
Cell surface:FH,FHR3:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Factor I inactivates MCP/CR1-bound C4b/C3b (Homo sapiens)
CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Homo sapiens)
CD46, CR1:C4b:C3b complexes [plasma membrane] (Homo sapiens)
CD46:Cell surface:C3b [plasma membrane] (Homo sapiens)
Cell surface:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
CR1:C3b [plasma membrane] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)
CFI:CFH:C3b [extracellular region] (Homo sapiens)
CFH:C3b [extracellular region] (Homo sapiens)
C3b [extracellular region] (Homo sapiens)
General
Linked by disulphide bond between positions 559 and 816.
Participants
components
C3 beta chain [extracellular region] (Homo sapiens)
C3b alpha' [extracellular region] (Homo sapiens)
Participant Of
input
C3b binds to cell surface
Factor H binds to C3b
output
C3 convertases spontaneously dissociate
C3(H2O):Factor Bb cleaves C3 to C3b and C3a
Cleavage of C3 by C3 convertases
hasComponent
C3b:Bb:C3b:Properdin [plasma membrane]
CD55:C3b [plasma membrane]
Cell surface:C3b [plasma membrane]
Cell surface:C3b:Bb [plasma membrane]
Cell surface:C3b:Bb:Properdin [plasma membrane]
CFH:C3b [extracellular region]
CR1:C3b [plasma membrane]
Inferred To
C3b [extracellular region] (Bos taurus)
C3b [extracellular region] (Canis familiaris)
C3b [extracellular region] (Danio rerio)
C3b [extracellular region] (Drosophila melanogaster)
C3b [extracellular region] (Gallus gallus)
C3b [extracellular region] (Mus musculus)
C3b [extracellular region] (Rattus norvegicus)
C3b [extracellular region] (Sus scrofa)
C3b [extracellular region] (Xenopus tropicalis)
Cross References
ComplexPortal
CPX-973
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