Reactome | CR2 [plasma membrane]

CR2 [plasma membrane]

Stable Identifier

R-HSA-197936

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Complement receptor type 2, CR2_HUMAN, CD21

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P20023 CR2

Gene Names

CR2, C3DR

Chain

signal peptide:1-20, chain:21-1033

Reference Genes

BioGPS Gene:1380 CR2

COSMIC (genes):CR2 CR2

CTD Gene:1380 CR2

dbSNP Gene:1380 CR2

ENSEMBL:ENSG00000117322 CR2

HGNC:2336 CR2

KEGG:hsa:1380 CR2

Monarch:1380 CR2

NCBI Gene:1380 CR2

OMIM:120650 CR2

UCSC:P20023 CR2

Reference Transcript

Other Identifiers

11721794_a_at

11756900_a_at

1380

16676795

205544_PM_s_at

205544_s_at

2377284

2377285

2377286

2377287

2377288

2377289

2377296

2377297

2377298

2377299

2377300

2377301

2377302

2377303

2377304

2377305

2377306

2377307

2377308

2377309

2377310

2377311

2377312

2377313

2377314

2377315

2377317

2377321

2377323

2377325

36874_at

7909350

A_14_P126654

A_24_P936376

A_33_P3281985

A_33_P3303697

GE62392

GO:0001618

GO:0001848

GO:0002376

GO:0002430

GO:0002456

GO:0003677

GO:0004875

GO:0004888

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006955

GO:0006957

GO:0006958

GO:0016020

GO:0030154

GO:0030183

GO:0034987

GO:0042100

GO:0042113

GO:0042803

GO:0043226

GO:0043235

GO:0045087

GO:0045959

GO:0046718

GO:0060089

GO:0060337

GO:0070062

GO:0098542

HMNXSV003015039

ILMN_1684724

ILMN_1727753

ILMN_2369666

M26004_s_at

PH_hs_0031301

S62696_s_at

TC01001737.hg

TC01004988.hg

g4503026_3p_a_at

g4503026_3p_x_at

Participates

as an input of

CR2 binds C3d, C3dg, iC3b (Homo sapiens)

as a component of

CR2:C3d,C3dg,iC3b [plasma membrane] (Homo sapiens)

Inferred To

CT26106 [plasma membrane] (Drosophila melanogaster)

Cr2 [plasma membrane] (Mus musculus)

Cr2 [plasma membrane] (Rattus norvegicus)

LOC490269 [plasma membrane] (Canis familiaris)

Homologues of CR2 [plasma membrane] (Gallus gallus)

CR2 [plasma membrane] (Bos taurus)

CR2 [plasma membrane] (Gallus gallus)

CR2 [plasma membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000356024, ENST00000367057, ENST00000367058, ENSG00000117322, ENSP00000356025

OpenTargets

ENSG00000117322

GeneCards

CR2

HPA

ENSG00000117322-CR2

PRO

P20023

Pharos - Targets

P20023

GlyGen

P20023

Orphanet

CR2

PDB

1W2R, 2ATY, 1GHQ, 1LY2, 1W2S, 2GSX, 8SM0, 3OED

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01024 C3	20	C3a [extracellular region] (R-HSA-166828) dNQ-C3(672-1663) [extracellular region] (R-HSA-182452) C3 beta chain [extracellular region] (R-HSA-166821) C3b alpha' [extracellular region] (R-HSA-166830) C3 alpha chain [extracellular region] (R-HSA-166820) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3 beta chain [plasma membrane] (R-HSA-977593) C3f [extracellular region] (R-HSA-976779) C3d [plasma membrane] (R-HSA-8853248) C3dg [plasma membrane] (R-HSA-3266505) C3a-desArg [extracellular region] (R-HSA-8852808) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 beta chain [secretory granule lumen] (R-HSA-6801014) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [azurophil granule lumen] (R-HSA-6799159)	0.719	4

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