Reactome | EFEMP2 [extracellular region]

EFEMP2 [extracellular region]

Stable Identifier

R-HSA-2161231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

FBLN4, Fibulin-4, EGF-containing fibulin-like extracellular matrix protein 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95967 EFEMP2

Gene Names

EFEMP2, FBLN4, UNQ200/PRO226

Chain

signal peptide:1-23, chain:24-443

Reference Genes

BioGPS Gene:30008 EFEMP2

COSMIC (genes):EFEMP2 EFEMP2

CTD Gene:30008 EFEMP2

dbSNP Gene:30008 EFEMP2

ENSEMBL:ENSG00000172638 EFEMP2

HGNC:3219 EFEMP2

KEGG:hsa:30008 EFEMP2

Monarch:30008 EFEMP2

NCBI Gene:30008 EFEMP2

OMIM:604633 EFEMP2

UCSC:O95967 EFEMP2

Reference Transcript

RefSeq:NM_016938.5 EFEMP2

Other Identifiers

11728351_a_at

11728352_x_at

11750280_x_at

16740577

206580_PM_s_at

206580_s_at

209356_PM_x_at

209356_x_at

30008

3377934

3377935

3377936

3377937

3377938

3377939

3377940

3377941

3377942

3377943

3377944

3377945

3377946

3377947

3377948

3377949

3377950

3377951

3377952

3377953

3377954

3377955

3377956

3377957

3377958

3377959

3377960

3377961

3377962

35347_at

63644_at

7949503

A_23_P24414

A_33_P3367830

GE54811

GO:0001527

GO:0005198

GO:0005201

GO:0005509

GO:0005515

GO:0005576

GO:0005604

GO:0008201

GO:0030198

GO:0030312

GO:0031012

GO:0035904

GO:0042803

GO:0043226

GO:0048251

GO:0048856

GO:0060414

GO:0062023

GO:0070062

GO:0071953

GO:0097084

GO:1903561

GO:1904026

GO:1904028

GO:1904706

GO:1904831

GO:1905609

HMNXSV003052030

ILMN_1653203

PH_hs_0018623

TC11001946.hg

TC11003210.hg

g7328920_3p_a_at

Participates

as a member of

Fibulins [extracellular region] (Homo sapiens)

Inferred To

efemp2a [extracellular region] (Danio rerio)

Efemp2 [extracellular region] (Mus musculus)

Efemp2 [extracellular region] (Rattus norvegicus)

efemp2 [extracellular region] (Xenopus tropicalis)

Dmel\CG32373 [extracellular region] (Drosophila melanogaster)

EFEMP2 [extracellular region] (Bos taurus)

EFEMP2 [extracellular region] (Canis familiaris)

EFEMP2 [extracellular region] (Dictyostelium discoideum)

Cross References

RefSeq

NP_058634.4

ENSEMBL

ENST00000307998, ENST00000531972, ENSG00000172638, ENSP00000309953, ENSP00000435295

OpenTargets

ENSG00000172638

GeneCards

EFEMP2

HPA

ENSG00000172638-EFEMP2

PRO

O95967

Pharos - Targets

O95967

Orphanet

EFEMP2

HMDB Protein

HMDBP13403

PDB

2KL7

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15502 ELN	3	ELN [extracellular region] (R-HSA-1454880) ELN(?-786) [extracellular region] (R-HSA-2514775) ELN(27-?) [extracellular region] (R-HSA-2514783)	0.645	5
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.611	3
UniProt:P35555 FBN1	7	FBN1(28-2731) [extracellular region] (R-HSA-2159853) FBN1 [endoplasmic reticulum lumen] (R-HSA-8956726) p-FBN1 [endoplasmic reticulum lumen] (R-HSA-8956900) FBN1 [extracellular region] (R-HSA-265402) FBN1(28-?) [extracellular region] (R-HSA-2514785) FBN1(1-2731) [extracellular region] (R-HSA-2514817) FBN1(2732-2871) [extracellular region] (R-HSA-2159838)	0.611	3
UniProt:Q99572 P2RX7	1	P2RX7 [plasma membrane] (R-HSA-877215)	0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:P56524 HDAC4	3	HDAC4 [nucleoplasm] (R-HSA-351581) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029)	0.556	3
UniProt:P10745 RBP3	1	RBP3 [extracellular region] (R-HSA-2984190)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:P01024 C3	20	C3a [extracellular region] (R-HSA-166828) dNQ-C3(672-1663) [extracellular region] (R-HSA-182452) C3 beta chain [extracellular region] (R-HSA-166821) C3b alpha' [extracellular region] (R-HSA-166830) C3 alpha chain [extracellular region] (R-HSA-166820) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3 beta chain [plasma membrane] (R-HSA-977593) C3f [extracellular region] (R-HSA-976779) C3d [plasma membrane] (R-HSA-8853248) C3dg [plasma membrane] (R-HSA-3266505) C3a-desArg [extracellular region] (R-HSA-8852808) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 beta chain [secretory granule lumen] (R-HSA-6801014) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [azurophil granule lumen] (R-HSA-6799159)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.553	2
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.508	3

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