Reactome | EFEMP2 [extracellular region]

EFEMP2 [extracellular region]

Stable Identifier

R-HSA-2161231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

FBLN4, Fibulin-4, EGF-containing fibulin-like extracellular matrix protein 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95967 EFEMP2

Gene Names

EFEMP2, FBLN4, UNQ200/PRO226

Chain

signal peptide:1-23, chain:24-443

Reference Genes

BioGPS Gene:30008 EFEMP2

COSMIC (genes):EFEMP2 EFEMP2

CTD Gene:30008 EFEMP2

dbSNP Gene:30008 EFEMP2

ENSEMBL:ENSG00000172638 EFEMP2

HGNC:3219 EFEMP2

KEGG Gene (Homo sapiens):30008 EFEMP2

Monarch:30008 EFEMP2

NCBI Gene:30008 EFEMP2

OMIM:604633 EFEMP2

UCSC:O95967 EFEMP2

Reference Transcript

RefSeq:NM_016938.4 EFEMP2

Other Identifiers

0007050487

11728351_a_at

11728352_x_at

11750280_x_at

16740577

206580_s_at

209356_x_at

30008

3377934

3377935

3377936

3377937

3377938

3377939

3377940

3377943

3377944

3377945

3377947

3377949

3377951

3377952

3377953

3377955

3377956

3377959

3377960

3377962

35347_at

63644_at

7949503

A_23_P24414

A_33_P3367830

GE54811

GO:0001527

GO:0003674

GO:0005198

GO:0005201

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005604

GO:0005615

GO:0007155

GO:0008150

GO:0008201

GO:0008283

GO:0022607

GO:0030154

GO:0030198

GO:0031012

GO:0035904

GO:0042803

GO:0043167

GO:0043226

GO:0048251

GO:0048856

GO:0060414

GO:0062023

GO:0070062

GO:0071953

GO:0097084

GO:1903561

GO:1904026

GO:1904028

GO:1904706

GO:1904831

GO:1905609

HMNXSV003052030

ILMN_1653203

PH_hs_0018623

TC11001946.hg

TC11003210.hg

g7328920_3p_a_at

Participates

as a member of

Fibulins [extracellular region] (Homo sapiens)

Inferred To

efemp2a [extracellular region] (Danio rerio)

Efemp2 [extracellular region] (Mus musculus)

Efemp2 [extracellular region] (Rattus norvegicus)

EFEMP2 [extracellular region] (Bos taurus)

EFEMP2 [extracellular region] (Canis familiaris)

EFEMP2 [extracellular region] (Dictyostelium discoideum)

EFEMP2 [extracellular region] (Xenopus tropicalis)

frac [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_058634.4

OpenTargets

ENSG00000172638

GeneCards

O95967

HPA

ENSG00000172638-EFEMP2

Ensembl

ENSP00000435295, ENST00000531972, ENST00000307998, ENSG00000172638, ENSP00000309953

PRO

O95967

Pharos - Targets

O95967

GlyGen

O95967

Orphanet

15914

PDB

2KL7

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15502 ELN	3	ELN(?-786) [extracellular region] (R-HSA-2514775) ELN [extracellular region] (R-HSA-1454880) ELN(27-?) [extracellular region] (R-HSA-2514783)	0.645	5
UniProt:P35555 FBN1	7	FBN1 [extracellular region] (R-HSA-265402) p-FBN1 [endoplasmic reticulum lumen] (R-HSA-8956900) FBN1(1-2731) [extracellular region] (R-HSA-2514817) FBN1(2732-2871) [extracellular region] (R-HSA-2159838) FBN1(28-?) [extracellular region] (R-HSA-2514785) FBN1 [endoplasmic reticulum lumen] (R-HSA-8956726) FBN1(28-2731) [extracellular region] (R-HSA-2159853)	0.611	3
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.611	3
UniProt:P01024 C3	20	C3 beta chain [extracellular region] (R-HSA-166821) C3a-desArg [extracellular region] (R-HSA-8852808) C3 alpha chain [extracellular region] (R-HSA-166820) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3 alpha chain [azurophil granule lumen] (R-HSA-6799161) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3 beta chain [plasma membrane] (R-HSA-977593) C3d [plasma membrane] (R-HSA-8853248) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3f [extracellular region] (R-HSA-976779) C3 beta chain [secretory granule lumen] (R-HSA-6801014) C3dg [plasma membrane] (R-HSA-3266505) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3b alpha' [extracellular region] (R-HSA-166830) C3d fragment [extracellular region] (R-HSA-198999) C3 beta chain [azurophil granule lumen] (R-HSA-6799159) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.556	3
UniProt:P10745 RBP3	1	RBP3 [extracellular region] (R-HSA-2984190)	0.556	3
UniProt:Q99572 P2RX7	1	P2RX7 [plasma membrane] (R-HSA-877215)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [cytosol] (R-HSA-162411) TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:P56524 HDAC4	3	SUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) SUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.553	2
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.508	3

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