Reactome | EFEMP2 [extracellular region]

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EFEMP2

Stable Identifier

R-HSA-2161231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

FBLN4, Fibulin-4, EGF-containing fibulin-like extracellular matrix protein 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95967 EFEMP2

Gene Names

EFEMP2, FBLN4, UNQ200/PRO226

Chain

signal peptide:1-25, chain:26-443

Reference Genes

BioGPS Gene:30008 EFEMP2

COSMIC (genes):EFEMP2 EFEMP2

CTD Gene:30008 EFEMP2

dbSNP Gene:30008 EFEMP2

ENSEMBL:ENSG00000172638 EFEMP2

HGNC:3219 EFEMP2

KEGG Gene (Homo sapiens):hsa:30008 EFEMP2

Monarch:30008 EFEMP2

NCBI Gene:30008 EFEMP2

OMIM:604633 EFEMP2

UCSC:O95967 EFEMP2

Reference Transcript

RefSeq:NM_016938.4 EFEMP2

Other Identifiers

0007050487

11728351_a_at

11728352_x_at

11750280_x_at

16740577

206580_s_at

209356_x_at

23270

2KL7

30008

3377934

3377935

3377936

3377937

3377938

3377939

3377940

3377943

3377944

3377945

3377947

3377949

3377951

3377952

3377953

3377955

3377956

3377959

3377960

3377962

35347_at

63644_at

7949503

A0A024R5G1

A_23_P24414

A_33_P3367830

CCDS8116

EFEMP2

EFEMP2-201

EFEMP2-217

ENSG00000172638

ENSP00000309953

ENSP00000435295

ENST00000307998

ENST00000531972

EntrezGene:30008

g7328920_3p_a_at

GE54811

GO:0005201

GO:0005509

GO:0005515

GO:0005576

GO:0005604

GO:0005615

GO:0048251

GO:0070062

GO:1903561

HGNC:3219

HPA023270

ILMN_1653203

MIM:604633

MIM:614437

NM_016938

NP_058634

NR_037718

PF07645

PF12662

PH_hs_0018623

PR00907

SM00179

SM00181

TC11001946.hg

TC11003210.hg

uc001ofy.5

uc058dqn.1

UPI000013EC97

Participant Of

hasMember

Fibulins [extracellular region]

Inferred To

EFEMP2 [extracellular region] (Bos taurus)

EFEMP2 [extracellular region] (Caenorhabditis elegans)

EFEMP2 [extracellular region] (Canis familiaris)

EFEMP2 [extracellular region] (Danio rerio)

EFEMP2 [extracellular region] (Drosophila melanogaster)

EFEMP2 [extracellular region] (Mus musculus)

EFEMP2 [extracellular region] (Rattus norvegicus)

EFEMP2 [extracellular region] (Sus scrofa)

EFEMP2 [extracellular region] (Xenopus tropicalis)

Homologues of EFEMP2 [extracellular region] (Danio rerio)

Homologues of EFEMP2 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_058634.4

GeneCards

O95967

PRO

O95967

Orphanet

15914

PDB

2KL7

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15502 ELN	3	ELN(?-786) [extracellular region] (R-HSA-2514775) ELN(27-?) [extracellular region] (R-HSA-2514783) ELN [extracellular region] (R-HSA-1454880)	0.645	5
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.611	3
UniProt:P35555 FBN1	7	FBN1 [endoplasmic reticulum lumen] (R-HSA-8956726) FBN1 [extracellular region] (R-HSA-265402) p-FBN1 [endoplasmic reticulum lumen] (R-HSA-8956900) FBN1(28-2731) [extracellular region] (R-HSA-2159853) FBN1(28-?) [extracellular region] (R-HSA-2514785) FBN1(1-2731) [extracellular region] (R-HSA-2514817) FBN1(2732-2871) [extracellular region] (R-HSA-2159838)	0.611	3
UniProt:Q12154	1	ASNA1 [endoplasmic reticulum membrane] (R-SCE-5216083)	0.556	3
UniProt:P56524 HDAC4	3	SUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) SUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) HDAC4 [nucleoplasm] (R-HSA-351581)	0.556	3
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.508	3
UniProt:P10745 RBP3	1	RBP3 [extracellular region] (R-HSA-2984190)	0.488	2
UniProt:P01024 C3	22	p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3d fragment [extracellular region] (R-HSA-198999) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3a-desArg [extracellular region] (R-HSA-8852808) C3dg [plasma membrane] (R-HSA-3266505) C3d [plasma membrane] (R-HSA-8853248) C3f [extracellular region] (R-HSA-976779) C3 beta chain [plasma membrane] (R-HSA-977593) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [secretory granule lumen] (R-HSA-6801014) C3 alpha chain [azurophil granule lumen] (R-HSA-6799161) C3 beta chain [azurophil granule lumen] (R-HSA-6799159) dNQ-C3(672-1663) [extracellular region] (R-HSA-182452) C3 alpha chain [extracellular region] (R-HSA-166820) C3b alpha' [extracellular region] (R-HSA-166830) C3 beta chain [extracellular region] (R-HSA-166821) C3a [extracellular region] (R-HSA-166828)	0.488	2
UniProt:Q99572 P2RX7	1	P2RX7 [plasma membrane] (R-HSA-877215)	0.488	2
UniProt:Q9H2F3 HSD3B7	1	HSD3B7 [endoplasmic reticulum membrane] (R-HSA-193441)	0.488	2