Reactome | C3d fragment [extracellular region]

C3d fragment [extracellular region]

Stable Identifier

R-HSA-198999

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C3(1002-1303)

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01024 C3

Gene Names

C3, CPAMD1

Chain

signal peptide:1-22, chain:23-1663, chain:23-667, chain:569-667, chain:672-1663, chain:672-748, chain:672-747, chain:749-1663, chain:749-954, chain:955-1303, chain:955-1001, chain:1002-1303, peptide:1304-1320, chain:1321-1663

Reference Genes

COSMIC (genes):C3 C3

dbSNP Gene:718 C3

ENSEMBL:ENSG00000125730 C3

Participates

as a component of

C3d complexed with antigen [extracellular region] (Homo sapiens)

Other forms of this molecule

C3 alpha chain [azurophil granule lumen]

C3 beta chain [azurophil granule lumen]

C3 alpha chain [secretory granule lumen]

C3 beta chain [secretory granule lumen]

p-C3 [endoplasmic reticulum lumen]

C3 [endoplasmic reticulum lumen]

C3c alpha' chain fragment 1 precursor [extracellular region]

C3c alpha' chain fragment 2 [extracellular region]

C3c alpha' chain fragment 1 [extracellular region]

C3a-desArg [extracellular region]

C3dg [plasma membrane]

C3d [plasma membrane]

C3f [extracellular region]

C3 beta chain [plasma membrane]

C3c alpha' chain fragment 1 precursor [plasma membrane]

C3c alpha' chain fragment 2 [plasma membrane]

C3 alpha chain [extracellular region]

C3b alpha' [extracellular region]

C3 beta chain [extracellular region]

dNQ-C3(672-1663) [extracellular region]

C3a [extracellular region]

Inferred To

LOC100491968 [extracellular region] (Xenopus tropicalis)

C3 [extracellular region] (Bos taurus)

C3 [extracellular region] (Canis familiaris)

C3 [extracellular region] (Mus musculus)

C3 [extracellular region] (Rattus norvegicus)

C3 [extracellular region] (Sus scrofa)

C3d fragment [extracellular region] (Gallus gallus)

Homologues of C3d fragment [extracellular region] (Xenopus tropicalis)

c3a.2 [extracellular region] (Danio rerio)

LOC100170611 [extracellular region] (Xenopus tropicalis)

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-12735745 C3B			0.801	12
UniProt:P08603 CFH	1	CFH [extracellular region] (R-HSA-976788)	0.743	6
UniProt:P20023 CR2	1	CR2 [plasma membrane] (R-HSA-197936)	0.719	4
UniProt:P15529 CD46	1	CD46 [plasma membrane] (R-HSA-977362)	0.623	2
UniProt:O60741 HCN1	1	HCN1 [plasma membrane] (R-HSA-977503)	0.623	7
UniProt:Q92496-1 CFHR4			0.609	5
UniProt:Q9Y279-1 VSIG4			0.591	5
ChEBI:28304 HEPARIN			0.589	2
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:O95994 AGR2			0.556	3
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:P35219 CAH8			0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:Q9Y279-2 VSIG4			0.524	2
UniProt:Q13936 CACNA1C	1	CACNA1C [plasma membrane] (R-HSA-265551)	0.499	2

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