Reactome | HCN1 [plasma membrane]

HCN1 [plasma membrane]

Stable Identifier

R-HSA-977503

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, HCN1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60741 HCN1

Gene Names

HCN1, BCNG1

Chain

chain:1-890

Reference Genes

BioGPS Gene:348980 HCN1

COSMIC (genes):HCN1 HCN1

CTD Gene:348980 HCN1

dbSNP Gene:348980 HCN1

ENSEMBL:ENSG00000164588 HCN1

ENSEMBL_homo_sapiens_GENE:ENSG00000164588.8 HCN1

HGNC:4845 HCN1

KEGG Gene (Homo sapiens):348980 HCN1

Monarch:348980 HCN1

NCBI Gene:348980 HCN1

OMIM:602780 HCN1

UCSC:O60741 HCN1

Reference Transcript

RefSeq:NM_021072.3 HCN1

Other Identifiers

11733546_s_at

11733547_a_at

1556351_PM_at

1556351_at

1562563_PM_at

1562563_at

16996017

2855961

2855962

2855964

2855965

2855966

2855967

2855968

2855969

2855972

2855974

2855975

2855978

2855980

2855981

2855984

2855998

2856007

2856008

2856009

348980

61131_at

8111998

A_23_P113019

A_32_P123143

A_32_P16138

GE652564

GO:0000166

GO:0003254

GO:0005215

GO:0005216

GO:0005222

GO:0005248

GO:0005249

GO:0005267

GO:0005272

GO:0005515

GO:0005886

GO:0006811

GO:0006813

GO:0006814

GO:0016020

GO:0019228

GO:0022843

GO:0030154

GO:0030424

GO:0030425

GO:0030552

GO:0034220

GO:0034702

GO:0035725

GO:0042391

GO:0042802

GO:0045176

GO:0045211

GO:0046549

GO:0048787

GO:0048856

GO:0050877

GO:0051289

GO:0051867

GO:0055085

GO:0060078

GO:0065003

GO:0071320

GO:0071805

GO:0098855

GO:0098978

GO:0110165

GO:0140232

HMNXSV003002838

Hs2.353176.1.S1_3p_at

ILMN_1687404

PH_hs_0003431

PH_hs_0023959

TC05001329.hg

Participates

as a component of

HCN channel Homomer of subunit HCN1 [plasma membrane] (Homo sapiens)

Inferred To

hcn1 [plasma membrane] (Xenopus tropicalis)

HCN1 [plasma membrane] (Bos taurus)

HCN1 [plasma membrane] (Canis familiaris)

HCN1 [plasma membrane] (Gallus gallus)

HCN1 [plasma membrane] (Mus musculus)

HCN1 [plasma membrane] (Rattus norvegicus)

HCN1 [plasma membrane] (Sus scrofa)

Ih [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_066550.2

Guide to Pharmacology - Targets

400

OpenTargets

ENSG00000164588

ZINC - Substances

HCN1_HUMAN

ZINC target

O60741

PRO

O60741

PDB

6UQF, 5U6O, 6UQG, 5U6P

HPA

ENSG00000164588-HCN1

GeneCards

O60741

Ensembl

ENSP00000307342, ENST00000303230, ENSG00000164588

Pharos - Targets

O60741

Orphanet

23069

ZINC - Predictions - Purchasable

HCN1_HUMAN

HMDB Protein

HMDBP01126

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.499	3
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.499	4
UniProt:P01024 C3	20	C3d fragment [extracellular region] (R-HSA-198999) C3 alpha chain [azurophil granule lumen] (R-HSA-6799161) C3 beta chain [azurophil granule lumen] (R-HSA-6799159) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [secretory granule lumen] (R-HSA-6801014) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3a-desArg [extracellular region] (R-HSA-8852808) C3dg [plasma membrane] (R-HSA-3266505) C3d [plasma membrane] (R-HSA-8853248) C3f [extracellular region] (R-HSA-976779) C3 beta chain [plasma membrane] (R-HSA-977593) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3 alpha chain [extracellular region] (R-HSA-166820) C3b alpha' [extracellular region] (R-HSA-166830) C3 beta chain [extracellular region] (R-HSA-166821)	0.499	6