Reactome | POM121 [nuclear envelope]

POM121 [nuclear envelope]

Stable Identifier

R-HSA-157747

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Locations in the PathwayBrowser for interactor UniProt:Q8IYF3 TEX11

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
        
        POM121 binds the Nup107-Nup160 complex (Homo sapiens)
        
        POM121 [nuclear envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96HA1 POM121

Gene Names

POM121, KIAA0618, NUP121, POM121A

Chain

chain:1-1249

Reference Genes

BioGPS Gene:9883 POM121

COSMIC - genes:POM121 POM121

CTD Gene:9883 POM121

dbSNP Gene:9883 POM121

ENSEMBL:ENSG00000196313 POM121

HGNC:19702 POM121

KEGG:hsa:9883 POM121

Monarch:9883 POM121

NCBI Gene:9883 POM121

OMIM:615753 POM121

UCSC:Q96HA1 POM121

Reference Transcript

Participates

as a component of

POM121:Nup107-160 complex:AHCTF1:Chromatin [nuclear envelope] (Homo sapiens)

as an input of

POM121 binds the Nup107-Nup160 complex (Homo sapiens)

as a member of

POM121 [nuclear envelope] (Homo sapiens)

Inferred To

LOC110258677 [nuclear envelope] (Sus scrofa)

Pom121 [nuclear envelope] (Mus musculus)

Pom121 [nuclear envelope] (Rattus norvegicus)

Homologues of POM121 [nuclear envelope] (Sus scrofa)

POM121 [nuclear envelope] (Sus scrofa)

LOC100627016 [nuclear envelope] (Sus scrofa)

npp-14 [nuclear envelope] (Caenorhabditis elegans)

Nup214 [nuclear envelope] (Drosophila melanogaster)

NPAP1 [nuclear envelope] (Sus scrofa)

POM121C [nuclear envelope] (Bos taurus)

POM121C [nuclear envelope] (Canis familiaris)

POM121C [nuclear envelope] (Gallus gallus)

POM121C [nuclear envelope] (Sus scrofa)

Ghost homologue of POM121 [nuclear envelope] (Danio rerio)

Ghost homologue of POM121 [nuclear envelope] (Schizosaccharomyces pombe)

Ghost homologue of POM121 [nuclear envelope] (Xenopus tropicalis)

Cross References

RefSeq

NP_001374627.1, NP_001374616.1, NP_001374618.1, NP_001374628.1, NP_001374617.1, NP_001374614.1, NP_001374624.1, NP_001374626.1, NP_001374625.1, NP_001374615.1, NP_001244119.1, NP_742017.1, NP_001374620.1, NP_001374629.1

OpenTargets

ENSG00000196313

ENSEMBL

ENSP00000486504, ENSP00000405562, ENSG00000196313, ENSP00000378687, ENST00000434423, ENST00000395270, ENST00000627934

GeneCards

POM121

HPA

ENSG00000196313-POM121

PRO

Q96HA1

Pharos - Targets

Q96HA1

GlyGen

Q96HA1

PDB

5T6W

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51116 FXR2			0.666	4
UniProt:Q93062 RBPMS			0.666	4
UniProt:O95994 AGR2			0.666	4
UniProt:Q8IYF3 TEX11			0.666	4
UniProt:P55345 ANM2			0.643	5
UniProt:Q96JJ6 JPH4			0.643	3
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.556	3
UniProt:Q6ZW49-2 PAXIP1			0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.527	2
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.527	2
UniProt:Q8IV45 UN5CL			0.527	2
UniProt:A4D1S0 KLRG2			0.527	2
UniProt:Q6UXL0 IL20RB	1	IL20RB [plasma membrane] (R-HSA-448709)	0.527	2
UniProt:Q9UGM1 CHRNA9	1	CHRNA9 [plasma membrane] (R-HSA-507827)	0.527	2
UniProt:P20036 HLA-DPA1	9	HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane] (R-HSA-197586) HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (R-HSA-2130639) HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130435) HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130485) HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane] (R-HSA-2130648) HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130337) HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane] (R-HSA-2214387) HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130739) HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130667)	0.527	2
UniProt:Q96G97 BSCL2			0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:O15482 TEX28			0.527	2
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.527	2
UniProt:Q9Y6H6 KCNE3	1	KCNE3 [plasma membrane] (R-HSA-977536)	0.527	2
UniProt:Q9NRJ7 PCDBG			0.527	2
UniProt:O43291 SPINT2	1	SPINT2 [extracellular region] (R-HSA-6800233)	0.527	2
UniProt:P11686 SFTPC	9	pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.527	3
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.527	2
UniProt:Q13557 CAMK2D	6	p-T287-CAMK2D [cytosol] (R-HSA-445370) CAMK2D [cytosol] (R-HSA-9611357) p-T287-CAMK2D [endocytic vesicle membrane] (R-HSA-417002) p-T287-CAMK2D [nucleoplasm] (R-HSA-444785) p-T287-CAMK2D [plasma membrane] (R-HSA-432794) p-T287-CAMK2D [endoplasmic reticulum membrane] (R-HSA-9948086)	0.527	2
UniProt:Q8WWF5 ZNRF4			0.527	2
UniProt:Q504Y0 S39AC			0.527	2
UniProt:O14595 CTDSP2	1	CTDSP2 [nucleoplasm] (R-HSA-535488)	0.527	2
UniProt:P54253 ATX1			0.488	2

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