POM121 binds the Nup107-Nup160 complex

Stable Identifier
R-HSA-9618378
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Based on studies in Xenopus (Fichtman et al. 2010) and human (Schwartz et al. 2015) models, POM121 binds the Nup107-160 complex through direct interaction with NUP133, a subunit of the Nup107-160 complex. Binding of POM121 to the Nup107-160 complex precedes formation of the nuclear pore diffusion barrier (Dultz et al. 2008), and is followed by recruitment of FG repeat nucleoporins (Fichtman et al. 2010). FG nucleoporins contain phenylalanine-glycine repeats needed for interaction with soluble nuclear import and export receptors (Frey et al. 2006).

Literature References
PubMed ID Title Journal Year
25602437 Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin

Schwartz, M, Travesa, A, Martell, SW, Forbes, DJ

Nucleus 2015
18316408 Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells

Dultz, E, Zanin, E, Wurzenberger, C, Braun, M, Rabut, G, Sironi, L, Ellenberg, J

J. Cell Biol. 2008
Participants
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