Reactome | POM121 binds the Nup107-Nup160 complex

POM121 binds the Nup107-Nup160 complex

Stable Identifier

R-HSA-9618378

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
        
        POM121 binds the Nup107-Nup160 complex (Homo sapiens)

General

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Based on studies in Xenopus (Fichtman et al. 2010) and human (Schwartz et al. 2015) models, POM121 binds the Nup107-160 complex through direct interaction with NUP133, a subunit of the Nup107-160 complex. Binding of POM121 to the Nup107-160 complex precedes formation of the nuclear pore diffusion barrier (Dultz et al. 2008), and is followed by recruitment of FG repeat nucleoporins (Fichtman et al. 2010). FG nucleoporins contain phenylalanine-glycine repeats needed for interaction with soluble nuclear import and export receptors (Frey et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
18316408	Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells Dultz, E, Zanin, E, Wurzenberger, C, Braun, M, Rabut, G, Sironi, L, Ellenberg, J	J. Cell Biol.	2008
25602437	Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin Schwartz, M, Travesa, A, Martell, SW, Forbes, DJ	Nucleus	2015