Reactome | HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane]

Stable Identifier

R-HSA-2130639

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

HA2Q_HUMAN, HLA-DPA1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P20036 HLA-DPA1

Gene Names

HLA-DPA1, HLA-DP1A, HLASB

Chain

signal peptide:1-28, chain:29-260

Reference Genes

BioGPS Gene:3113 HLA-DPA1

COSMIC (genes):HLA-DPA1 HLA-DPA1

CTD Gene:3113 HLA-DPA1

dbSNP Gene:3113 HLA-DPA1

ENSEMBL:ENSG00000231389 HLA-DPA1

HGNC:4938 HLA-DPA1

KEGG:hsa:3113 HLA-DPA1

Monarch:3113 HLA-DPA1

NCBI Gene:3113 HLA-DPA1

OMIM:142880 HLA-DPA1

UCSC:P20036 HLA-DPA1

Reference Transcript

Other Identifiers

11715583_s_at

11757511_x_at

11758231_x_at

11758417_s_at

17018039

17027187

17029847

17032533

17034851

17037331

17040037

17042548

211990_PM_at

211990_at

211991_PM_s_at

211991_s_at

213537_PM_at

213537_at

2950330

2950331

2950332

2950333

2950334

2950335

2950336

2950337

2950338

2950339

2950340

2950341

2950342

2950343

2950344

2950345

2950346

2950347

2950348

2950349

2950350

2950351

2950352

2950354

3113

38833_at

54984_at

8125556

8178891

8180100

91041_at

A_23_P30913

A_24_P243528

A_33_P3234277

GE83655

GE85212

GE85578

GE85654

GE85658

GO:0000139

GO:0002250

GO:0002376

GO:0002503

GO:0002504

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006955

GO:0009986

GO:0010008

GO:0012507

GO:0016020

GO:0019882

GO:0019886

GO:0023026

GO:0030658

GO:0030666

GO:0030669

GO:0031410

GO:0031902

GO:0032395

GO:0032588

GO:0032729

GO:0042102

GO:0042605

GO:0042613

GO:0043226

GO:0043231

GO:0050778

GO:0050870

GO:0060089

GO:0065003

GO:0071346

GO:0098553

HMNXSV003055523

Hs.914.0.A1_3p_a_at

Hs.914.1.A1_3p_at

ILMN_1772218

PH_hs_0000113

PH_hs_0035313

TC06001578.hg

TC6_apd_hap1000107.hg

TC6_cox_hap2000202.hg

TC6_dbb_hap3000188.hg

TC6_mann_hap4000170.hg

TC6_mcf_hap5000177.hg

TC6_qbl_hap6000190.hg

TC6_ssto_hap7000172.hg

X03100_cds2_at

Participates

as a member of

HLA II alpha chain [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane]

Inferred To

hla-dpa1 [lysosomal membrane] (Danio rerio)

mhc2-daa [lysosomal membrane] (Xenopus tropicalis)

si:busm1-194e12.8 [lysosomal membrane] (Danio rerio)

RT1-Ha [lysosomal membrane] (Rattus norvegicus)

mhc2daa [lysosomal membrane] (Danio rerio)

Homologues of HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (Danio rerio)

mhc2d8.45b1 [lysosomal membrane] (Danio rerio)

mhc2dgb [lysosomal membrane] (Danio rerio)

Cross References

RefSeq

NP_001229453.1, NP_001229454.1, NP_291032.2

OpenTargets

ENSG00000231389

ENSEMBL

ENSP00000397139, ENSP00000509163, ENSP00000393566, ENST00000415247, ENSP00000405838, ENST00000419277, ENST00000454805, ENST00000692443, ENSP00000397587, ENSP00000363941, ENSP00000406250, ENSP00000427429, ENST00000422504, ENST00000383224, ENST00000515317, ENST00000443117, ENSP00000372711, ENST00000374808

HPA

ENSG00000231389-HLA-DPA1

PRO

P20036

Pharos - Targets

P20036

PDB

3LQZ, 4P4K, 4P5K, 4P4R, 7T2A, 7T2C, 4P5M, 7T2B, 4P57, 7T2D

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7KYR7 BTN2A1	1	BTN2A1 [plasma membrane] (R-HSA-8851994)	0.527	2
UniProt:Q9ULX3 NOB1	2	NOB1 [nucleoplasm] (R-HSA-6791536) NOB1 [cytosol] (R-HSA-6791524)	0.527	2
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:P16260 SLC25A16	1	SLC25A16 [mitochondrial inner membrane] (R-HSA-199229)	0.527	2
UniProt:Q86X52 CHSY1	5	CHSY1 P539R [Golgi membrane] (R-HSA-3636862) CHSY1 E33Sfs2 [Golgi membrane] (R-HSA-3636864) CHSY1 Q69 [Golgi membrane] (R-HSA-3636838) CHSY1 G19_L28del [Golgi membrane] (R-HSA-3636823) CHSY1 [Golgi membrane] (R-HSA-1971431)	0.527	2
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.527	2
UniProt:P02649 APOE	10	APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.527	2
UniProt:P48645 NMU	1	NMU [extracellular region] (R-HSA-964817)	0.527	3
UniProt:Q14118 DAG1	15	DAG1 [endoplasmic reticulum membrane] (R-HSA-9913254) DAG1(654-895) [endoplasmic reticulum membrane] (R-HSA-9913257) DAG1(654-895) [Golgi membrane] (R-HSA-9913184) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [Golgi lumen] (R-HSA-8932424) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region] (R-HSA-9913190) GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(654-895) [plasma membrane] (R-HSA-2328154)	0.527	2
UniProt:Q96BI1 SLC22A18	3	SLC22A18 R286H [plasma membrane] (R-HSA-5625583) SLC22A18 S233F [plasma membrane] (R-HSA-5625564) SLC22A18 [plasma membrane] (R-HSA-561110)	0.527	2

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