Reactome | HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane]

Stable Identifier

R-HSA-2130337

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

Synonyms

HA2Q_HUMAN, HLA-DPA1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P20036 HLA-DPA1

Gene Names

HLA-DPA1, HLA-DP1A, HLASB

Chain

signal peptide:1-28, chain:29-260

Reference Genes

BioGPS Gene:3113 HLA-DPA1

COSMIC (genes):HLA-DPA1 HLA-DPA1

CTD Gene:3113 HLA-DPA1

dbSNP Gene:3113 HLA-DPA1

ENSEMBL:ENSG00000231389 HLA-DPA1

ENSEMBL_homo_sapiens_GENE:ENSG00000168384.11 HLA-DPA1

ENSEMBL_homo_sapiens_GENE:ENSG00000206291.10 HLA-DPA1

ENSEMBL_homo_sapiens_GENE:ENSG00000224103.7 HLA-DPA1

ENSEMBL_homo_sapiens_GENE:ENSG00000228163.8 HLA-DPA1

ENSEMBL_homo_sapiens_GENE:ENSG00000229685.8 HLA-DPA1

ENSEMBL_homo_sapiens_GENE:ENSG00000231389.8 HLA-DPA1

ENSEMBL_homo_sapiens_GENE:ENSG00000235844.8 HLA-DPA1

ENSEMBL_homo_sapiens_GENE:ENSG00000236177.9 HLA-DPA1

HGNC:4938 HLA-DPA1

KEGG Gene (Homo sapiens):3113 HLA-DPA1

Monarch:3113 HLA-DPA1

NCBI Gene:3113 HLA-DPA1

OMIM:142880 HLA-DPA1

Reference Transcript

Other Identifiers

11715583_s_at

11757511_x_at

11758231_x_at

11758417_s_at

17018039

17027187

17029847

17032533

17034851

17037331

17040037

17042548

211990_PM_at

211990_at

211991_PM_s_at

211991_s_at

2950330

2950331

2950332

2950333

2950338

2950340

2950341

2950342

2950343

2950345

2950346

2950348

2950349

2950350

2950352

3113

38833_at

8125556

8178891

8180100

91041_at

A_23_P30913

A_24_P243528

A_33_P3234277

GE83655

GE85658

GO:0000139

GO:0002250

GO:0002376

GO:0002503

GO:0002504

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006955

GO:0007155

GO:0009986

GO:0010008

GO:0012507

GO:0016020

GO:0019882

GO:0019886

GO:0023026

GO:0030658

GO:0030666

GO:0030669

GO:0031410

GO:0031902

GO:0032395

GO:0032588

GO:0032729

GO:0042102

GO:0042605

GO:0042613

GO:0043226

GO:0043231

GO:0050778

GO:0050870

GO:0060089

GO:0065003

GO:0071346

GO:0098542

GO:0098553

HMNXSV003055523

Hs.914.0.A1_3p_a_at

ILMN_1772218

PH_hs_0000113

PH_hs_0035313

TC06001578.hg

TC6_apd_hap1000107.hg

TC6_cox_hap2000202.hg

TC6_dbb_hap3000188.hg

TC6_mann_hap4000170.hg

TC6_mcf_hap5000177.hg

TC6_qbl_hap6000190.hg

TC6_ssto_hap7000172.hg

X03100_cds2_at

Participates

as a member of

HLA II alpha chain [trans-Golgi network membrane] (Homo sapiens)

Other forms of this molecule

HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane]

HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane]

Inferred To

hla-dpa1 [trans-Golgi network membrane] (Danio rerio)

mhc2daa [trans-Golgi network membrane] (Danio rerio)

si:busm1-194e12.8 [trans-Golgi network membrane] (Danio rerio)

mhc2d8.45b1 [trans-Golgi network membrane] (Danio rerio)

RT1-Ha [trans-Golgi network membrane] (Rattus norvegicus)

mhc2-daa [trans-Golgi network membrane] (Xenopus tropicalis)

mhc2dgb [trans-Golgi network membrane] (Danio rerio)

Homologues of HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (Danio rerio)

Cross References

RefSeq

NP_001229453.1, NP_291032.2, NP_001229454.1

OpenTargets

ENSG00000231389

HPA

ENSG00000231389-HLA-DPA1

GeneCards

P20036

Ensembl

ENSG00000231389, ENSP00000406250, ENSG00000206291, ENSG00000229685, ENST00000422504, ENST00000692443, ENST00000515317, ENSP00000363941, ENST00000415247, ENSP00000397139, ENSP00000372711, ENSP00000509163, ENSP00000393566, ENSP00000397587, ENSG00000224103, ENST00000374808, ENST00000454805, ENST00000419277, ENST00000443117, ENSG00000235844, ENSG00000236177, ENSP00000427429, ENSP00000405838, ENSG00000168384, ENSG00000228163, ENST00000383224

PRO

P20036

Pharos - Targets

P20036

PDB

4P4R, 4P4K, 4P5K, 4P57, 4P5M, 7T2A, 7T2C, 7T2B, 3LQZ, 7T2D

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BI1 SLC22A18	3	SLC22A18 [plasma membrane] (R-HSA-561110) SLC22A18 S233F [plasma membrane] (R-HSA-5625564) SLC22A18 R286H [plasma membrane] (R-HSA-5625583)	0.527	2
UniProt:Q7KYR7 BTN2A1	1	BTN2A1 [plasma membrane] (R-HSA-8851994)	0.527	2
UniProt:P48645 NMU	1	NMU [extracellular region] (R-HSA-964817)	0.527	3
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE-4 [extracellular region] (R-HSA-9711070) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.527	2
UniProt:P16260 SLC25A16	1	SLC25A16 [mitochondrial inner membrane] (R-HSA-199229)	0.527	2
UniProt:Q9ULX3 NOB1	2	NOB1 [nucleoplasm] (R-HSA-6791536) NOB1 [cytosol] (R-HSA-6791524)	0.527	2
UniProt:Q14118 DAG1	10	GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(654-895) [plasma membrane] (R-HSA-2328154)	0.527	2
UniProt:Q86X52 CHSY1	5	CHSY1 P539R [Golgi membrane] (R-HSA-3636862) CHSY1 E33Sfs2 [Golgi membrane] (R-HSA-3636864) CHSY1 Q69 [Golgi membrane] (R-HSA-3636838) CHSY1 G19_L28del [Golgi membrane] (R-HSA-3636823) CHSY1 [Golgi membrane] (R-HSA-1971431)	0.527	2
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.527	2

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