Reactome | fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B

fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B

Stable Identifier

R-HSA-140840

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

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fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B

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The alpha and beta chains of fibrinogen hexamer are cleaved by thrombin to generate fibrin monomer (Ni et al. 1989). The amino terminal regions of the cleaved alpha and beta chains are released (fibrinopeptides A and B respectively).

Literature References

PubMed ID	Title	Journal	Year
2742826	High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen Ni, F, Konishi, Y, Frazier, RB, Scheraga, HA, Lord, ST	Biochemistry	1989