fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B

Stable Identifier
R-HSA-140840
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
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fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
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The alpha and beta chains of fibrinogen hexamer are cleaved by thrombin to generate fibrin monomer (Ni et al. 1989). The amino terminal regions of the cleaved alpha and beta chains are released (fibrinopeptides A and B respectively).

Literature References
PubMed ID Title Journal Year
2742826 High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen

Ni, F, Konishi, Y, Frazier, RB, Scheraga, HA, Lord, ST

Biochemistry 1989
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
Physical Entity
activated thrombin (factor IIa) [extracellular region]
Activity
serine-type endopeptidase activity (0004252)
This event is regulated
Negatively by
Orthologous Events
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Rattus norvegicus)
Authored
D'Eustachio, P  (2004-08-24)
Created
D'Eustachio, P  (2004-08-24)