Reactome | Upon TLR7/8 or 9 stimulation IRF7, but not IRF3, forms a sig...

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created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975120
displayName	Upon TLR7/8 or 9 stimulation IRF7, but not IRF3, forms a sig...
literatureReference	[LiteratureReference:933491] Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 [LiteratureReference:975069] Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling [LiteratureReference:975472] Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
modified	[InstanceEdit:975490] Shamovsky, V, 2010-09-24
schemaClass	Summation
text	Upon TLR7/8 or 9 stimulation IRF7, but not IRF3, forms a signaling complex with MyD88, TRAF6[Honda K et al 2004, Kawai T et al 2004], IRAK1 [Uematsu S et al 2005], Also IRAK4 was shown to mediate IRF7 activation[Honda K et al 2004].

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