Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation

Stable Identifier
R-HSA-975106
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Influenza A virus, Human immunodeficiency virus 1, Human SARS coronavirus
Compartment
cytosol, endosome membrane
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Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
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IRF7 is phosphorylated on Ser477 and Ser479 residues [Lin R et al 2000] . IRAK1[Uematsu et al 2005] and IKK alpha[Hoshino et al 2006] are thought to mediate the phosphorylation upon TLR7/8/9 activation.

Literature References
PubMed ID Title Journal Year
11073981 Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain

Marié, I, Smith, E, Prakash, A, Levy, DE

Mol Cell Biol 2000
15767370 Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

Uematsu, S, Sato, S, Yamamoto, M, Hirotani, T, Kato, H, Takeshita, F, Matsuda, M, Coban, C, Ishii, KJ, Kawai, T, Takeuchi, O, Akira, S

J Exp Med 2005
Participants
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Output
Participant Of
hasEvent
Authored
Shamovsky, V  (2010-08-25)
Reviewed
Gillespie, ME  (2010-10-29)
Created
Shamovsky, V  (2010-09-22)
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