Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation

Stable Identifier
R-HSA-975106
Type
Reaction
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, endosome membrane
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Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
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IRF7 is phosphorylated on Ser477 and Ser479 residues [Lin R et al 2000] . IRAK1[Uematsu et al 2005] and IKK alpha[Hoshino et al 2006] are thought to mediate the phosphorylation upon TLR7/8/9 activation.

Literature References
PubMed ID Title Journal Year
15767370 Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

Takeuchi, O, Yamamoto, M, Matsuda, M, Ishii, KJ, Sato, S, Akira, S, Kawai, T, Kato, H, Coban, C, Hirotani, T, Uematsu, S, Takeshita, F

J Exp Med 2005
11073981 Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain

Marié, I, Prakash, A, Smith, E, Levy, DE

Mol Cell Biol 2000
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Authored
Shamovsky, V  (2010-08-25)
Reviewed
Gillespie, ME  (2010-10-29)
Created
Shamovsky, V  (2010-09-22)
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