Reactome | IRF7 is phosphorylated on Ser477 and Ser479 residues [Lin R...

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created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975162
displayName	IRF7 is phosphorylated on Ser477 and Ser479 residues [Lin R...
literatureReference	[LiteratureReference:500613] Multiple regulatory domains control IRF-7 activity in response to virus infection [LiteratureReference:500618] TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1 [LiteratureReference:975083] IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9 [LiteratureReference:975093] Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells
schemaClass	Summation
text	IRF7 is phosphorylated on Ser477 and Ser479 residues [Lin R et al 2000] . IRAK1[Uematsu et al 2005] and IKK alpha[Hoshino et al 2006] are thought to mediate the phosphorylation upon TLR7/8/9 activation.

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