Reactome | p-T,Y MAPK8,9 translocate to the nucleus

Schema > BlackBoxEvent > Entries

p-T,Y MAPK8,9 translocate to the nucleus Show undefined attributes

authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9851075] Rothfels, Karen, 2023-10-12
crossReference	[DatabaseIdentifier:12020842] Mondo:0020325
dbId	9851079
disease	[Disease:9699595] anaplastic large cell lymphoma [Disease:1500689] cancer
displayName	p-T,Y MAPK8,9 translocate to the nucleus
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9851076] p-T,Y MAPK8,9 bind TP53 - Homo sapiens [BlackBoxEvent:R-HSA-9851098] NPM1-ALK- and JUN-dependent CDKN1A gene repression - Homo sapiens
input	[DefinedSet:R-HSA-9850925] p-T,Y MAPK8,9 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9725249] NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma
maxDepth	1
modified	[InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	p-T,Y MAPK8,9 translocate to the nucleus
output	[DefinedSet:R-HSA-9850928] p-T,Y MAPK8,9 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9851078] NPM1-ALK-dependent MAPK8,9 phosphorylation - Homo sapiens
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9851079
summation	[Summation:9850809] After NPM1-ALK-stimulated phosphorylation, MAPK8 and 9 promo...

Referrals

(precedingEvent)	[Reaction:R-HSA-9851076] p-T,Y MAPK8,9 bind TP53 [BlackBoxEvent:R-HSA-9851098] NPM1-ALK- and JUN-dependent CDKN1A gene repression
(hasEvent)	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants

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