Reactome | Nuclear events stimulated by ALK signaling in cancer

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Nuclear events stimulated by ALK signaling in cancer Show undefined attributes

authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
created	[InstanceEdit:9725372] Rothfels, Karen, 2021-03-29
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9725371
disease	[Disease:1500689] cancer
displayName	Nuclear events stimulated by ALK signaling in cancer
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9701810] MECP2 binds the STAT5A gene - Homo sapiens [BlackBoxEvent:R-HSA-9701903] ALK-, STAT3- and MECP2-dependent STAT5A gene repression - Homo sapiens [BlackBoxEvent:R-HSA-9725009] NPM1-ALK translocates to the nucleus - Homo sapiens [Reaction:R-HSA-9725023] NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 - Homo sapiens [Reaction:R-HSA-9725030] MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner - Homo sapiens [BlackBoxEvent:R-HSA-9725342] NPM1-ALK-dependent JUNB gene transcription - Homo sapiens [BlackBoxEvent:R-HSA-9725345] NPM1-ALK-dependent JUNB translation - Homo sapiens [Reaction:R-HSA-9851084] JUNB dimer binds GZMB promoter - Homo sapiens [BlackBoxEvent:R-HSA-9851088] JUNB- and NPM1-ALK-mediated GZMB gene expression - Homo sapiens [BlackBoxEvent:R-HSA-9851131] NPM1-ALK-stimulated PRF1 gene expression - Homo sapiens [BlackBoxEvent:R-HSA-9725338] NPM1-ALK-dependent BCL2A1 gene expression - Homo sapiens [BlackBoxEvent:R-HSA-9725357] NPM1-ALK-dependent CEBPB gene expression - Homo sapiens [Reaction:R-HSA-9851106] p-Y705, S727 STAT3 dimer binds ICOS promoter - Homo sapiens [BlackBoxEvent:R-HSA-9851104] NPM1-ALK- and STAT3-dependent ICOS gene expression - Homo sapiens [BlackBoxEvent:R-HSA-9851109] NPM1-ALK- and STAT3-dependent TWIST gene expression - Homo sapiens [Reaction:R-HSA-9851118] pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK - Homo sapiens [BlackBoxEvent:R-HSA-9851117] NPM1-ALK- and p-STAT3-dependent IRF4 gene expression - Homo sapiens [Reaction:R-HSA-9851090] NPM1-ALK binds NPM1 and FOXM1 - Homo sapiens [BlackBoxEvent:R-HSA-9851092] NPM1-ALK and FOXM1-dependent CCNB1 gene expression - Homo sapiens [BlackBoxEvent:R-HSA-9851068] Crizotinib-driven IL10RA gene expression in NPM1-ALK - Homo sapiens [Reaction:R-HSA-9851122] p-Y705,S727 STAT3 dimer binds NOTCH gene - Homo sapiens [BlackBoxEvent:R-HSA-9851123] NPM1-ALK- and p-STAT3-dependent NOTCH gene expression - Homo sapiens [Reaction:R-HSA-9851071] STAT3, DNMT1 and HDAC1 bind PTPN6 gene - Homo sapiens [BlackBoxEvent:R-HSA-9851072] DNMT1-dependent PTPN6 gene silencing - Homo sapiens [Reaction:R-HSA-9851062] AcK685 pY705,S727 STAT3 binds the MIR21 gene - Homo sapiens [BlackBoxEvent:R-HSA-9851139] STAT3-dependent MIR-21 gene expression - Homo sapiens [Reaction:R-HSA-9851147] miR-21 RISC binds DNMT1 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9851145] Translation of DNMT1 mRNA is repressed by miR-21 - Homo sapiens [Reaction:R-HSA-9851064] AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9851137] STAT3-dependent DNMT1 gene expression - Homo sapiens [BlackBoxEvent:R-HSA-9851133] STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing - Homo sapiens [BlackBoxEvent:R-HSA-9851127] NPM1-ALK-dependent repression of pRB phosphorylation - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer [LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer [LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology [LiteratureReference:9718441] The role of the ALK receptor in cancer biology [LiteratureReference:9724958] The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis
maxDepth	2
modified	[InstanceEdit:9853043] Rothfels, Karen, 2023-11-09
name	Nuclear events stimulated by ALK signaling in cancer
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9725371
summation	[Summation:9725539] Signaling through oncogenic forms of ALK activate nuclear ev...
updateTrackers	[UpdateTracker:9853195] Update Tracker - [Pathway:9725371] Nuclear events stimulated by ALK signaling in cancer - v87:[addHasEvent, modifyText, updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants
(updatedInstance)	[UpdateTracker:9853195] Update Tracker - [Pathway:9725371] Nuclear events stimulated by ALK signaling in cancer - v87:[addHasEvent, modifyText, updateContainedRLE]

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