Reactome | ALK mutants bind STAT3

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ALK mutants bind STAT3 Show undefined attributes

authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9712080] Rothfels, Karen, 2021-01-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9712079
disease	[Disease:1500689] cancer
displayName	ALK mutants bind STAT3
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9712085] ALK mutants phosphorylate STAT3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-539044] STAT3 [cytosol] [CandidateSet:R-HSA-9711944] STAT3-activating ALK mutants [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9701321] Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death [LiteratureReference:9701412] Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma [LiteratureReference:9701338] Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma [LiteratureReference:9701343] NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors [LiteratureReference:9716071] EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer [LiteratureReference:9701376] Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer [LiteratureReference:9701357] Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer [LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology [LiteratureReference:9718441] The role of the ALK receptor in cancer biology [LiteratureReference:9710767] Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas [LiteratureReference:9711805] A novel KIF5B-ALK variant in nonsmall cell lung cancer [LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease [LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma [LiteratureReference:9701348] Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma [LiteratureReference:9701408] Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma [LiteratureReference:9701292] Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3 [LiteratureReference:9701315] JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells [LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3 [LiteratureReference:9723824] Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma [LiteratureReference:9723810] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALK mutants bind STAT3
normalReaction	[BlackBoxEvent:R-HSA-9701524] STAT3 is phosphorylated downstream of active ALK
output	[Complex:R-HSA-9711935] STAT3-activating ALK mutants:STAT3 [cytosol]
precedingEvent	[Reaction:R-HSA-9700181] Autophosphorylation of ALK fusions - Homo sapiens [Reaction:R-HSA-9700186] Autophosphorylation of point mutants of ALK - Homo sapiens
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9712079
summation	[Summation:9724095] The STAT3 signaling pathway is a major downstream target of ...

Referrals

(hasEvent)	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants
(precedingEvent)	[Reaction:R-HSA-9712085] ALK mutants phosphorylate STAT3

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