Reactome | Autophosphorylation of point mutants of ALK

Schema > Reaction > Entries

Autophosphorylation of point mutants of ALK Show undefined attributes

authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
catalystActivity	[CatalystActivity:9700108] protein tyrosine kinase activity of ALK point mutant dimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9700185] Rothfels, Karen, 2020-09-14
dbId	9700186
disease	[Disease:1500689] cancer
displayName	Autophosphorylation of point mutants of ALK
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9700190] ALK mutants bind SHC - Homo sapiens [Reaction:R-HSA-9710917] ALK fusion proteins bind PLCG1 - Homo sapiens [Reaction:R-HSA-9712079] ALK mutants bind STAT3 - Homo sapiens [BlackBoxEvent:R-HSA-9712078] ALK mutants bind PI3KR1 - Homo sapiens
input	[DefinedSet:R-HSA-9700436] ALK point mutant dimers [plasma membrane] 14 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9700372] Oncogenic mutations of ALK kinase in neuroblastoma [LiteratureReference:9701722] Identification of ALK as a major familial neuroblastoma predisposition gene [LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma [LiteratureReference:9715255] Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer [LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma [LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology [LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autophosphorylation of point mutants of ALK
normalReaction	[Reaction:R-HSA-201521] ALK autophosphorylation
output	14 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-9700566] p-7Y ALK point mutant dimers [plasma membrane]
precedingEvent	[Reaction:R-HSA-9700184] Ligand-independent dimerization of point mutants of ALK - Homo sapiens
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9700186
summation	[Summation:9723305] Oncogenic point mutations in ALK promote ligand-independent ...

Referrals

(hasEvent)	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants
(precedingEvent)	[Reaction:R-HSA-9700190] ALK mutants bind SHC [Reaction:R-HSA-9710917] ALK fusion proteins bind PLCG1 [Reaction:R-HSA-9712079] ALK mutants bind STAT3 [BlackBoxEvent:R-HSA-9712078] ALK mutants bind PI3KR1