Reactome | ALK fusions phosphorylate IRS1

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ALK fusions phosphorylate IRS1 Show undefined attributes

authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
catalystActivity	[CatalystActivity:9711936] protein tyrosine kinase activity of IRS:ALK fusion proteins [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9712080] Rothfels, Karen, 2021-01-14
dbId	9712082
disease	[Disease:1500689] cancer
displayName	ALK fusions phosphorylate IRS1
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9711940] IRS:ALK fusion proteins [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9699651] Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5) [LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition [LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALK fusions phosphorylate IRS1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9712076] p-Y IRS1:ALK fusion proteins [cytosol]
precedingEvent	[Reaction:R-HSA-9712088] ALK fusion proteins bind IRS - Homo sapiens
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9712082
summation	[Summation:9711764] IRS1 is phosphorylated downstream of NPM-ALK fusions (Fujimo...

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[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants