Reactome | ALK fusions phosphorylate PLCG1

Schema > Reaction > Entries

ALK fusions phosphorylate PLCG1 Show undefined attributes

authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
catalystActivity	[CatalystActivity:9711942] protein tyrosine kinase activity of PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9712080] Rothfels, Karen, 2021-01-14
dbId	9712086
disease	[Disease:1500689] cancer
displayName	ALK fusions phosphorylate PLCG1
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
eventOf	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9851137] STAT3-dependent DNMT1 gene expression - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9710910] PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9699741] Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer [LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALK fusions phosphorylate PLCG1
normalReaction	[Reaction:R-HSA-9700171] Active ALK phosphorylates PLCG1
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9712072] ALK fusions:p-4Y PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9710917] ALK fusion proteins bind PLCG1 - Homo sapiens
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9712086
summation	[Summation:9724121] PLC gamma is phosphorylated downstream of ALK fusions, activ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9851137] STAT3-dependent DNMT1 gene expression
(hasEvent)	[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants