Reactome | PDGFRA D842V [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-9674356] regorafenib-sensitive PDGFR mutants [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9672043] PDGFRA D842V dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9672043] PDGFRA D842V dimer [plasma membrane] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-9674398] D842V PDGFRA doesn't bind sunitinib - Homo sapiens [FailedReaction:R-HSA-9674408] Regorafenib-resistant PDGFR mutants don't bind regorafenib - Homo sapiens
created	[InstanceEdit:9671534] Rothfels, Karen, 2019-12-19
crossReference	[DatabaseIdentifier:12020834] Mondo:0011719 [DatabaseIdentifier:9671550] COSMIC:COSV57264120
dbId	9671549
disease	[Disease:1500689] cancer [Disease:9661830] gastrointestinal stromal tumor
displayName	PDGFRA D842V [plasma membrane]
endCoordinate	1089
hasModifiedResidue	[ReplacedResidue:9671533] L-aspartic acid 842 replaced with L-valine
inDisease	true
maxDepth	1
memberOf	[DefinedSet:R-HSA-9674354] ponatinib-sensitive PDGFR mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9674358] ripretinib sensitive PDGFR mutants [plasma membrane] - Homo sapiens
name	PDGFRA D842V Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P16234] UniProt:P16234 PDGFRA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9671549
startCoordinate	24

(hasCandidate)	[CandidateSet:R-HSA-9674356] regorafenib-sensitive PDGFR mutants [plasma membrane] [CandidateSet:R-HSA-9674353] quizartinib-sensitive PDGFR mutants [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-9674358] ripretinib sensitive PDGFR mutants [plasma membrane] [DefinedSet:R-HSA-9674354] ponatinib-sensitive PDGFR mutants [plasma membrane] [DefinedSet:R-HSA-9674344] avapritinib-sensitive PDGFR mutants [plasma membrane] [DefinedSet:R-HSA-9674340] midostaurin-sensitive PDGFR mutants [plasma membrane] [DefinedSet:R-HSA-9674343] crenolanib-sensitive PDGFR mutants [plasma membrane] [DefinedSet:R-HSA-9672125] imatinib-resistant PDGFR mutants [plasma membrane] [DefinedSet:R-HSA-9673718] sorafenib-resistant PDGFR mutants [plasma membrane] [CandidateSet:R-HSA-9672124] kinase domain mutants of PDGFRA [plasma membrane]
(input)	[FailedReaction:R-HSA-9674398] D842V PDGFRA doesn't bind sunitinib [FailedReaction:R-HSA-9674408] Regorafenib-resistant PDGFR mutants don't bind regorafenib
(diseaseEntity)	[EntityFunctionalStatus:9674406] loss_of_function of PDGFRA D842V [plasma membrane]
(hasComponent)	[Complex:R-HSA-9672043] PDGFRA D842V dimer [plasma membrane]