Reactome | quizartinib-sensitive PDGFR mutants [plasma membrane]

Schema > CandidateSet > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674355] Rothfels, Karen, 2020-01-13
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9674353
disease	[Disease:1500689] cancer
displayName	quizartinib-sensitive PDGFR mutants [plasma membrane]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-9671549] PDGFRA D842V [plasma membrane] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-9673603] PDGFRA T674I [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9674303] PDGFRA D842L [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9673573] Sorafenib is a potent inhibitor of FIP1L1-PDGFRalpha and the imatinib-resistant FIP1L1-PDGFRalpha T674I mutant [LiteratureReference:9674223] FIP1L1-PDGFR? p.T674I-D842L: A Novel and Ponatinib Resistant Compound Mutation in FIP1L1-PDGFR? Positive Leukemia
maxDepth	2
memberOf	[DefinedSet:R-HSA-9674351] type II TKI sensitive PDGFR mutants [plasma membrane] - Homo sapiens
name	quizartinib-sensitive PDGFR mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9674353

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