Reactome | midostaurin-sensitive PDGFR mutants [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674341] Rothfels, Karen, 2020-01-13
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9674340
disease	[Disease:1500689] cancer
displayName	midostaurin-sensitive PDGFR mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9671549] PDGFRA D842V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671557] PDGFRA V561D [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9671319] A precision therapy against cancers driven by KIT/PDGFRA mutations [LiteratureReference:9676836] Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity
maxDepth	2
memberOf	[DefinedSet:R-HSA-9674342] type I TKI sensitive PDGFR mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9676843] Rothfels, Karen, 2020-02-21
name	midostaurin-sensitive PDGFR mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9674340

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