Reactome | imatinib-resistant PDGFR mutants [plasma membrane]

Schema > DefinedSet > Entries

imatinib-resistant PDGFR mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9674397] Imatinib-resistant PDGFR mutants don't bind imatinib - Homo sapiens
created	[InstanceEdit:9672127] Rothfels, Karen, 2019-12-23
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9672125
disease	[Disease:1500689] cancer
displayName	imatinib-resistant PDGFR mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9671549] PDGFRA D842V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671547] PDGFRA D842_D846del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671545] PDGFRA D842_H845del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671563] PDGFRA D842_I843delinsV [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671526] PDGFRA D842_M844del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671538] PDGFRA D842del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671559] PDGFRA D843_844del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671552] PDGFRA D843_845del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671537] PDGFRA I843_D846del [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9673600] PDGFRA S601P [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9673603] PDGFRA T674I [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9671911] PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib [LiteratureReference:9673492] A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome [LiteratureReference:9672488] A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome [LiteratureReference:9673503] Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha [LiteratureReference:9671429] Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors [LiteratureReference:9673563] Primary resistance to imatinib in Fip1-like 1-platelet-derived growth factor receptor alpha-positive eosinophilic leukemia [LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
maxDepth	2
modified	[InstanceEdit:9676847] Rothfels, Karen, 2020-02-21
name	imatinib-resistant PDGFR mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9672125

Referrals

(input)	[FailedReaction:R-HSA-9674397] Imatinib-resistant PDGFR mutants don't bind imatinib
(diseaseEntity)	[EntityFunctionalStatus:9674394] loss_of_function of imatinib-resistant PDGFR mutants [plasma membrane]

© 2026 Reactome

Cite Us!