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Schema
>
FailedReaction
>
Entries
D842V PDGFRA doesn't bind sunitinib
Show undefined attributes
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authored
[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:9674407] Rothfels, Karen, 2020-01-13
dbId
9674398
disease
[Disease:1500689] cancer
displayName
D842V PDGFRA doesn't bind sunitinib
edited
[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus
[EntityFunctionalStatus:9674406] loss_of_function of PDGFRA D842V [plasma membrane]
eventOf
[Pathway:R-HSA-9674401] Sunitinib-resistant PDGFR mutants - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-9671549] PDGFRA D842V [plasma membrane]
[ChemicalDrug:R-ALL-9669720] sunitinib [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9674261] Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor
[LiteratureReference:9671429] Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors
[LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
D842V PDGFRA doesn't bind sunitinib
normalReaction
[Reaction:R-HSA-9674095] PDGFRs bind type II TKI
releaseDate
2020-03-17
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9674398
summation
[Summation:9674400] Sunitinib-resistant PDFGRA mutants include the D842V allele,...
Referrals
(hasEvent)
[Pathway:R-HSA-9674401] Sunitinib-resistant PDGFR mutants
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