Reactome | sorafenib-resistant PDGFR mutants [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9674414] Sorafenib-resistant PDGFR mutants don't bind sorefenib - Homo sapiens
created	[InstanceEdit:9673721] Rothfels, Karen, 2020-01-08
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9673718
disease	[Disease:1500689] cancer
displayName	sorafenib-resistant PDGFR mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9673600] PDGFRA S601P [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9671549] PDGFRA D842V [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9671429] Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors [LiteratureReference:9673492] A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome
maxDepth	2
modified	[InstanceEdit:9674386] Rothfels, Karen, 2020-01-13
name	sorafenib-resistant PDGFR mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9673718

(input)	[FailedReaction:R-HSA-9674414] Sorafenib-resistant PDGFR mutants don't bind sorefenib
(diseaseEntity)	[EntityFunctionalStatus:9674402] loss_of_function of sorafenib-resistant PDGFR mutants [plasma membrane]

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