Reactome | cAMP binds PKA tetramer

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cAMP binds PKA tetramer Show undefined attributes

authored	[InstanceEdit:112007] Le Novere, N, Jassal, B, 2004-03-31 12:22:05
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8951730] Jupe, Steve, 2016-12-09
dbId	8951727
displayName	cAMP binds PKA tetramer
edited	[InstanceEdit:8949504] Jupe, Steve, 2016-11-25 [InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
eventOf	[Pathway:R-HSA-163615] PKA activation - Homo sapiens [Pathway:R-HSA-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase - Homo sapiens [Pathway:R-HSA-180024] DARPP-32 events - Homo sapiens [Pathway:R-HSA-9660821] ADORA2B mediated anti-inflammatory cytokines production - Homo sapiens [Pathway:R-HSA-9634597] GPER1 signaling - Homo sapiens [Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis - Homo sapiens [Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Homo sapiens
followingEvent	[Reaction:R-HSA-111925] cAMP induces dissociation of inactive PKA tetramers - Homo sapiens
input	4 × [SimpleEntity:R-ALL-30389] cAMP [cytosol] [Complex:R-HSA-111922] PKA tetramer [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:379023] Dynamic binding of PKA regulatory subunit RI alpha
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	cAMP binds PKA tetramer
orthologousEvent	[Reaction:R-PFA-8951727] cAMP binds PKA tetramer - Plasmodium falciparum [Reaction:R-SCE-8951727] cAMP binds PKA tetramer - Saccharomyces cerevisiae [Reaction:R-SPO-8951727] cAMP binds PKA tetramer - Schizosaccharomyces pombe [Reaction:R-DDI-8951727] cAMP binds PKA tetramer - Dictyostelium discoideum [Reaction:R-CEL-8951727] cAMP binds PKA tetramer - Caenorhabditis elegans [Reaction:R-DME-8951727] cAMP binds PKA tetramer - Drosophila melanogaster [Reaction:R-GGA-8951727] cAMP binds PKA tetramer - Gallus gallus [Reaction:R-XTR-8951727] cAMP binds PKA tetramer - Xenopus tropicalis [Reaction:R-DRE-8951727] cAMP binds PKA tetramer - Danio rerio [Reaction:R-SSC-8951727] cAMP binds PKA tetramer - Sus scrofa [Reaction:R-BTA-8951727] cAMP binds PKA tetramer - Bos taurus [Reaction:R-RNO-8951727] cAMP binds PKA tetramer - Rattus norvegicus [Reaction:R-MMU-8951727] cAMP binds PKA tetramer - Mus musculus
output	[Complex:R-HSA-8951729] PKA tetramer:4xcAMP [cytosol]
precedingEvent	[Reaction:R-HSA-392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate - Homo sapiens [Reaction:R-HSA-164377] Activated Adenylate cyclase catalyses cAMP synthesis - Homo sapiens [Reaction:R-HSA-111930] Adenylate cyclase produces cAMP - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:379937] Castagnoli, L, 2008-11-06 12:55:54 [InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8951727
summation	[Summation:8951728] Protein kinase A (PKA) regulatory subunit isoforms differ in...
updateTrackers	[UpdateTracker:9778757] Update Tracker - [Reaction:8951727] cAMP binds PKA tetramer - v67:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9778757] Update Tracker - [Reaction:8951727] cAMP binds PKA tetramer - v67:[modifyText]
(hasEvent)	[Pathway:R-HSA-9660821] ADORA2B mediated anti-inflammatory cytokines production [Pathway:R-HSA-9664323] FCGR3A-mediated IL10 synthesis [Pathway:R-HSA-432040] Vasopressin regulates renal water homeostasis via Aquaporins [Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Pathway:R-HSA-9634597] GPER1 signaling [Pathway:R-HSA-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase [Pathway:R-HSA-180024] DARPP-32 events [Pathway:R-HSA-163615] PKA activation
(precedingEvent)	[Reaction:R-HSA-111925] cAMP induces dissociation of inactive PKA tetramers

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