Reactome | Regulation of PTEN gene transcription

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Regulation of PTEN gene transcription Show undefined attributes

authored	[InstanceEdit:6807125] Orlic-Milacic, Marija, 2015-10-29 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11 [InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11
created	[InstanceEdit:8943722] Orlic-Milacic, Marija, 2016-10-28
dbId	8943724
displayName	Regulation of PTEN gene transcription
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-6807070] PTEN Regulation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5632939] TP53 binds the PTEN promoter - Homo sapiens [Reaction:R-HSA-8944078] EGR1 binds the PTEN gene promoter - Homo sapiens [Reaction:R-HSA-8944099] Activated PPARG binds PTEN gene promoter - Homo sapiens [Reaction:R-HSA-6807077] NR2E1 associated with transcription repressors binds PTEN promoter - Homo sapiens [Reaction:R-HSA-8943728] SALL4 binds the PTEN gene promoter - Homo sapiens [Reaction:R-HSA-8943780] SALL4 recruits NuRD to PTEN gene - Homo sapiens [Reaction:R-HSA-8943811] MECOM (EVI1) binds the PTEN gene promoter - Homo sapiens [Reaction:R-HSA-8943817] MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter - Homo sapiens [Reaction:R-HSA-8944026] SNAI1,SNAI2 bind the PTEN gene promoter - Homo sapiens [Reaction:R-HSA-8944047] JUN binds the PTEN gene promoter - Homo sapiens [Reaction:R-HSA-8944397] p-T69,T71-ATF2 binds PTEN gene promoter - Homo sapiens [Reaction:R-HSA-8944454] mTORC1 phosphorylates MAF1 - Homo sapiens [BlackBoxEvent:R-HSA-8944457] MAF1 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-8944420] MAF1 binds the PTEN gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8944104] PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8942896] SALL4 is a key regulator of survival and apoptosis in human leukemic cells [LiteratureReference:994203] Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex [LiteratureReference:8942920] Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins [LiteratureReference:8942922] The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells [LiteratureReference:6807074] Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1 [LiteratureReference:8943321] Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras [LiteratureReference:8943309] Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis [LiteratureReference:8943317] SLUG is a direct transcriptional repressor of PTEN tumor suppressor [LiteratureReference:5632944] Regulation of PTEN transcription by p53 [LiteratureReference:8943330] The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling [LiteratureReference:8943341] Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN [LiteratureReference:8943334] Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells [LiteratureReference:8944385] MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Regulation of PTEN gene transcription
orthologousEvent	[Pathway:R-MMU-8943724] Regulation of PTEN gene transcription - Mus musculus [Pathway:R-RNO-8943724] Regulation of PTEN gene transcription - Rattus norvegicus [Pathway:R-CFA-8943724] Regulation of PTEN gene transcription - Canis familiaris [Pathway:R-BTA-8943724] Regulation of PTEN gene transcription - Bos taurus [Pathway:R-SSC-8943724] Regulation of PTEN gene transcription - Sus scrofa [Pathway:R-DRE-8943724] Regulation of PTEN gene transcription - Danio rerio [Pathway:R-XTR-8943724] Regulation of PTEN gene transcription - Xenopus tropicalis [Pathway:R-GGA-8943724] Regulation of PTEN gene transcription - Gallus gallus [Pathway:R-DME-8943724] Regulation of PTEN gene transcription - Drosophila melanogaster [Pathway:R-CEL-8943724] Regulation of PTEN gene transcription - Caenorhabditis elegans [Pathway:R-DDI-8943724] Regulation of PTEN gene transcription - Dictyostelium discoideum [Pathway:R-SPO-8943724] Regulation of PTEN gene transcription - Schizosaccharomyces pombe [Pathway:R-SCE-8943724] Regulation of PTEN gene transcription - Saccharomyces cerevisiae [Pathway:R-PFA-8943724] Regulation of PTEN gene transcription - Plasmodium falciparum
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8943724
summation	[Summation:8948727] Transcription of the PTEN gene is regulated at multiple leve...

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[Pathway:R-HSA-6807070] PTEN Regulation

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